141970-73-2

Upstream product

• 1122-91-4 4-bromo-benzaldehyde 
• 13139-17-8 N-(Benzyloxycarbonyloxy)succinimide 
• 122332-24-5 (R)-methyl 2-amino-3-(4-bromophenyl)propanoate 
• 100945-15-1 N-(benzyloxycarbonyl)phosphonoglycine trimethyl ester 
• 14091-15-7 p-bromo-DL-phenylalanine 
• 447461-10-1 methyl (Z)-2-(benzyloxycarbonyl)amino-3-(4-bromophenyl)acrylate 
• 67-56-1 methanol 
• 394210-38-9 4-(4-bromo-benzyl)-2,5-dioxo-oxazolidine-3-carboxylic acid benzyl ester 

Downstream Products

• 1431556-48-7 C₂₄H₂₁Cl₂NO₄ 
• 1431556-49-8 C₂₃H₁₉Cl₂NO₃ 
• 1431556-50-1 C₂₆H₂₅Cl₂NO₅ 
• 1431556-51-2 C₃₂H₂₉Cl₂NO₆ 
• 1431556-52-3 C₃₅H₃₃Cl₂NO₆ 
• 1431608-95-5 C₂₇H₂₇Cl₂NO₄ 
• 1431556-54-5 C₃₀H₃₁Cl₂NO₆ 

Relevant academic research and scientific papers

N-SUBSTITUTED 3,3'-(BIPHENYL-4,4'-DIYL)BIS-2-AMINOPROPANENITRILES AS DPPI INHIBITORS

The invention relates to a compound of Formula (I) and its use as a selective dipeptidyl peptidase I inhibitor, as well as pharmaceutical compositions comprising said compound, and methods of treatment involving said compounds.

Practical, asymmetric synthesis of aromatic-substituted bulky and hydrophobic tryptophan and phenylalanine derivatives

Aromatic ring substituted tryptophans and phenylalanines can provide valuable tools in developing highly potent and selective peptide ligands with specific structural features in addition to providing a large lipophilic surface for binding to receptors and for crossing membrane barriers. An efficient method for the synthesis of these novel amino acids has been developed. In the approach, asymmetric hydrogenations of α-enamides using Burk's DuPHOS-based Rh (I) catalysts generated high enantiomerically pure α-amino acid derivatives, which subsequently underwent Suzuki cross couplings with boronic acid derivatives to afford these aromatic substituted amino acids in high yields and high enantioselectivity. The method can allow for the preparation of such amino acids in large scales for extensive structure-activity studies.