1419829-29-0

Upstream product

• 82735-28-2 6-methoxy-3-(trichloromethyl)isobenzofuran-1(3H)-one 
• 1419827-39-6 2-(4-hydroxyphenyl)-7-methoxy-3-(4-methoxyphenyl)isoquinolin-1(2H)-one 
• 5472-49-1 1-(3-chloropropyl)piperidine hydrochloride 
• 586415-11-4 2-(β,β-dichloroethenyl)-5-methoxybenzoic acid 
• 123-30-8 4-amino-phenol 
• 586-38-9 3-Methoxybenzoic acid 
• 52962-25-1 2-(carboxymethyl)-5-methoxybenzoic acid 
• 14963-91-8 7-methoxy-3-(4-methoxyphenyl)-1H-isochromen-1-one 
• 2493-02-9 4-bromophenyl isocyanate 
• 104-58-5 3-piperidinopropan-1-ol 

Downstream Products

• 1419829-43-8 7-hydroxy-3-(4-hydroxyphenyl)-2-(4-(3-(piperidin-1-yl)propoxy)phenyl)isoquinolin-1(2H)-one 

Relevant academic research and scientific papers

Expeditious Synthesis of Isoquinolone Derivatives by Rhodium(I)-Catalyzed Annulation Reaction through C-C Bond Cleavage

A Rh(I)-catalyzed intermolecular cyclization between isocyanates and benzocyclobutenols leading to isoquinolin-1(2H)-ones through selective cleavage of a C-C bond has been realized. Exploiting the same strategy, we developed a Rh(I)-catalyzed three-component reaction of benzocyclobutenols, isonitriles, and sulfonyl azides to access isoquinolin-1(2H)-imines. These procedures provide unique and expeditious access to isoquinolone derivatives which are otherwise difficult to prepare in satisfactory yields with excellent functional-group tolerance under mild reaction conditions.

Synthesis and biological evaluation of 2,3-diaryl isoquinolinone derivatives as anti-breast cancer agents targeting ERα and VEGFR-2

The estrogen receptor α is recognized as important pharmaceutical target for breast cancer therapy, and vascular endothelial growth factor receptors (VEGFRs) play important roles in tumor angiogenesis including breast cancer. A series of 2,3-diaryl isoqui