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• 1118-71-4 2,2,6,6-tetramethylheptane-3,5-dione 
• 931-55-5 phenyl-diazene 
• 100-63-0 phenylhydrazine 

Relevant academic research and scientific papers

Direct Synthesis of 4-Organylselanylpyrazoles by Copper- Catalyzed One-Pot Cyclocondensation and C-H Bond Selenylation Reactions

We describe herein an efficient protocol to synthesize selanyl-substituted pyrazoles by cyclocondensation and copper-catalyzed direct C-H bond selenation reactions. The products were obtained in moderate to excellent yields by the one-pot multicomponent r

Synthesis, characterization and antibacterial applications of pyrazolyl-sulfonamides and their palladium complexes

A series of pyrazolyl sulfonamide compounds were prepared by a multi-step procedure involving preparation of phenyl pyrazolyl compounds (C1, C2) and their chlorosulfonated derivatives (C3-C5), which were then converted to sulfonamides (L1-L6). Complexes of L1-L6 with palladium(ii) show the standard trans square-planar coordination environment for the six complexes (1-6). All products were prepared in moderate to high yield (61-81%). All compounds were successfully characterized by NMR spectroscopy, IR spectroscopy, mass spectrometry and in one case single X-ray crystallography. Conversion of C1 and C2 to C3-C5 is governed by steric hindrance on the pyrazolyl group as sulfonation of the phenyl only is observed for tBu groups (C4), whereas for Me groups sulfonation of the pyrazolyl is observed C3 as well as phenyl ring for C5. Antimicrobial screening was carried out on the compounds using the agar-well diffusion method at varying concentrations of (62.5, 125, 250, 500 and 1000 μg mL-1) on ten (10) bacteria strains. The zone of inhibition for all the compounds are within the ranges of 9.5 mm to 25 mm compared to the control antibiotic, gentamicin that was between 16.5 mm to 36 mm. The compounds L1-L6 generally showed mild to strong antibacterial activity in the zones of inhibition against most Gram negative bacteria strains tested, but no activity against Gram positive bacteria strains Staphylococcus aureus and Enterococcus faecalis, except L4 which showed activity towards Staphylococcus. The palladium(ii) complexes generally showed improved activities for all the bacteria strains studied with 4 exhibiting the most potent in vitro anti-bacterial activity with MICs of 1.046 μg mL-1 and 0.237 μg mL-1 against Staphylococcus epidermidis and Proteus mirabilis respectively. Theoretical Log P calculation show values between 3.06 and 5.95 for the ligands and between 6.67 and 12.36 for complexes. Suggesting high affinity of these compounds to the lipophilic medium. However, the experimental Log P value gave a different trend, which shows that compounds with sulfonation only on the phenyl ring (L3 (-0.83), L4 (-0.53), 3 (-0.96) and 4 (-0.72)) have high affinity for the hydrophilic medium. This journal is

Efficient Copper-Catalyzed Synthesis of Substituted Pyrazoles at Room Temperature

An efficient method for the synthesis of pyrazoles through a copper-catalyzed condensation reaction has been developed. The new catalytic system not only maintained a broad substrate scope but was also active under acid-free reaction conditions, overcoming the conventional requirement for an acid-catalyzed system. Furthermore, the copper catalyst enabled this reaction to be performed at room temperature and in a short reaction time.

(13)C Chemical Shifts and (1)H - (13)C Coupling Constants of N-Phenyl-, N-p-Fluorophenyl- and N-o-Nitrophenylpyrazoles

The (13)C chemical shifts and some (1)H - (13)C coupling constants of twelve N-arylpyrazoles are reported.The assignments were made by using the effects of a fluorine substituent and two-dimensional techniques. Key words: (13)C chemical shifts, (1)H - (13