14199-59-8Relevant articles and documents
Antimicrobial, antimalarial, and cytotoxic substances from the insect pathogenic fungus Beauveria asiatica BCC 16812
Kornsakulkarn, Jittra,Pruksatrakul, Thapanee,Surawatanawong, Panida,Thangsrikeattigun, Chattawat,Komwijit, Somjit,Boonyuen, Nattawut,Thongpanchang, Chawanee
, p. 8 - 15 (2021/03/14)
Six new compounds 1–6 and two new naturally occurring compounds 7 and 8, together with nine known compounds 9–14, beauverioride I, dipicolinic acid, and 6-(methoxycarbonyl) picolinic acid were isolated from a wasp-pathogenic fungus Beauveria asiatica, strain BCC 16812. Their structures were determined by extensive spectroscopic analyses. The absolute configurations of compound 6 were established by the application of modified Mosher's method and ECD calculation. Compounds 9–11 exhibited antimalarial (IC50 0.47–1.79 u g/mL), antimicrobial (MIC 3.13–50.0 u g/mL), and cytotoxic (IC50 0.26–1.23 u g/mL) activities, while compounds 1, 2, 8, and 14 showed only cytotoxicity against Vero cell lines, with IC50 values range 12.96–47.03 u g/mL.
Bioactive compounds from the scale insect fungus Conoideocrella tenuis BCC 44534
Saepua, Siriporn,Kornsakulkarn, Jittra,Somyong, Wiwat,Laksanacharoen, Pattiyaa,Isaka, Masahiko,Thongpanchang, Chawanee
, p. 859 - 866 (2018/01/17)
Eleven new compounds, including two quinone derivatives of bioxanthracene, conoideocrellones A (1) and B (2), two bioxanthracenes 3 and 4, four isocoumarins and isocoumarin glycosides 7–10, two phenolic compounds 16 and 17, and a diterpenoid compound, conoideocin A (18), were isolated from culture of the scale-insect pathogenic fungus Conoideocrella tenuis BCC 44534. Seventeen known compounds, compounds 5 and 6, ES-242-2 and its atropisomer, isocoumarins and isocoumarin glycosides 11–15, 3,4,6-trihydroxymellein, cis-4,6-dihydroxymellein, metarhizins A (19) and B (20), BR-050 (21), 5α,8α-epidioxy-24(R)-methylcholesta-6,22-dien-3β-ol, zeorin, and conoideocrellide A, were also isolated from this fungus. Structures of these compounds were elucidated by NMR and MS data analyses. Compound 4 was active against Plasmodium falciparum K1 (IC50 6.6 μg/mL), while it did not show cytotoxicity. Conoideocrellone A (1) and compounds 3 and 7 exhibited cytotoxic activity, while conoideocin A (18) showed broad range of biological activities including antimalarial, antibacterial, and cytotoxic activities.
Isocoumarin glucosides from the scale insect fungus Torrubiella tenuis BCC 12732
Kornsakulkarn, Jittra,Thongpanchang, Chawanee,Lapanun, Sanisa,Srichomthong, Kitlada
experimental part, p. 1341 - 1343 (2010/02/28)
Three new isocoumarin glucosides (1, 3, and 4), 6,8-dihydroxy-3- methylisocoumarin (2), and 6,8-dihydroxy-3-hydroxymethylisocoumarin (5) were isolated from the scale insect pathogenic fungus Torrubiella tenuis BCC 12732. Structures of these compounds were
