39131-44-7Relevant articles and documents
Preparation and preliminary application of 5-HMF@SiO2 micro-particles
Wang, Cheng,He, Huaizhen,Lin, Yuanyuan,Huang, Limin,Sun, Meng,Zhang, Tao,He, Langchong
, p. 70586 - 70591 (2016)
A new approach for the surficial-modification of silica with 5-HMF as a functional molecule was first designed. The infrared spectrum, X-ray photoelectron spectroscopy and elemental analysis showed that the modified-SiO2 particles were successfully established. Full dispersion of SiO2 and the introduction of gallic acid were confirmed to be favorable for the 5-HMF content. The retention behavior of bovine serum albumin on the modified-SiO2 particle suggested that the novel particles could serve as a promising stationary phase on the identification of the particular proteins.
Synthesis of various cyclopropyl methyl bromide and its derivatives from ketones and/or aldehydes and some β-dicarbonyl compounds in the presence of BrCN and Et3N
Gholizadeh, Saeed,Safa, Kazem D.,Noroozi Pesyan, Nader
, p. 1239 - 1253 (2019/04/27)
The ultimate goal in this paper has been developed for the synthesis of structurally various bromomethyl cyclopropane via an α-bromoketone and/or aldehydes with ethyl cyanoacetate or malononitrile and cyanogen bromide (BrCN) in the presence of Et3N to give products in excellent yields within about 3?s. All structures were characterized by IR, 1H-NMR, 13C-NMR, and Mass spectroscopy techniques. The reaction mechanism was discussed.
Preparation of halogenated furfurals as intermediates in the carbohydrates to biofuel process
Meller, Elad,Aviv, Avishay,Aizenshtat, Zeev,Sasson, Yoel
, p. 36069 - 36076 (2016/05/19)
Lignocellulose derived halogenated furfurals are important chemicals that can serve as starting materials for diverse products such as drugs, polymers and fuels, including fuel additives. In this paper a protocol for the synthesis of 5-chloromethyl furfural (CMF) and 5-bromomethyl furfural (BMF) is put forward. The proposed process is based on a two liquid phases reaction composed of an aqueous hydrochloric or hydrobromic acid phase and 1,2-dichloroethane (DCE) organic phase. We have optimized and compared the yields of CMF and BMF in an open flask and in a closed reaction vessels. Utilization of the close reaction vessel resulted in not only higher yields in a shorter reaction time but also eliminated the necessity of the customary lithium salts additives previously advocated for this process. These additives were required in the open reaction systems in order to achieve reasonable yields. While a closed reaction vessel was previously reported for the production of CMF, and in this work its production was further improved, it is the first time a close vessel protocol for the production of BMF has been reported. In addition, improvement of the substrate to organic solvent ratio has been carried while yields of halogenated furfurals were maintained almost intact. NMR and UV-vis spectroscopy were used for identification and quantification of the products.
