141996-75-0Relevant academic research and scientific papers
3,6-Dioxoperhydropyrrolo[1,2-a]pyrazines as templates for peptidomimetics
Martin-Martinez, Mercedes,Garcia-Lopez, M. Teresa,Herranz, Rosario,Rosario, Gonzalez-Muniz
, p. 10361 - 10374 (2007/10/02)
The synthesis of 4,7-di- and 4,7,7-trisubstituted 3,6-dioxoperhydropyrrolo[1,2-a]pyrazine-7-carboxylate derivatives is described. The approach used for the preparation of this heterocyclic template is based on the reductive amination of 4-ketodiesters derived from dipeptides.
3,6-Dioxoperhydropyrrolo[1,2-a]pyrazines. A new approach to conformationally restricted tripeptides
Martin-Martinez,Garcia-Lopez,Gonzalez-Muniz
, p. 2187 - 2190 (2007/10/02)
Catalytic hydrogenation of the 4-ketodiesters, obtained from Z-Xaa-Gly (Xaa = Ala, Phe) halomethyl ketones and dimethyl malonate, provides readily access to the corresponding 4-substituted-3,6-dioxoperhydropyrrolo[1,2-a]pyrazine-7-carboxylic acid derivati
