142011-57-2Relevant academic research and scientific papers
PI-3 KINASE INHIBITOR PRODRUGS
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Page 44, (2010/02/09)
The invention provides novel prodrugs of inhibitors of PI-3 kinase. The novel compounds are LY294002 and analogs thereof comprising a reversibly quaternized amine.
Synthesis and hydrolytic stability studies of albendazole carrier prodrugs
Hernandez-Luis, Francisco,Hernandez-Campos, Alicia,Yepez-Mulia, Lilian,Cedillo, Roberto,Castillo, Rafael
, p. 1359 - 1362 (2007/10/03)
Three N-acyl (2, 3, and 4), two N-alkoxycarbonyl (5 and 6), and one N-acyloxymethyl (7) derivatives of albendazole (1) have been prepared and assessed as potential prodrugs. The determination of the aqueous solubility and partition coefficient, as well as the conversion of these derivatives to 1 in buffer solution, human plasma, and pig liver esterase were determined.
