49715-04-0Relevant articles and documents
Chloromethyl chlorosulfate: A new, catalytic method of preparation and reactions with some nucleophiles
Power, Nicholas P.,Bethell, Donald,Proctor, Lee,Latham, Elliot,Dawson, Paul
, p. 1554 - 1562 (2004)
A catalytic method of preparing chloromethyl chlorosulfate (CMCS) was described. The reaction of liquid SO3 with CH2Cl 2 at room temperature led to SO3 insertion into the C-Cl bonds, giving CMCS. The product mixtures consists entirely of CMCS and the product of further sulfation, methylene bis(chlorosulfate) (MBCS). The reaction was shown to be first order in the catalyst and third order in SO3 by measuring initial rates of CMCS formation or total CH2Cl2 consumption. The results show that the reaction between dichloromethane and SO3 at room temperature is accelerated by very low concentrations.
Development of a process for the preparation of chloromethyl chlorosulfate
Zheng, Bin,Sugiyama, Masano,Eastgate, Martin D.,Fritz, Alan,Murugesan, Saravanababu,Conlon, David A.
, p. 1827 - 1831 (2012)
A new and efficient synthesis of chloromethyl chlorosulfate (CMCS) from chloroiodomethane and chlorosulfonic acid is described. This process leverages a chlorosulfonic acid-mediated iodide oxidation to drive the equilibrating displacement process to full conversion. The resulting iodine byproduct is further oxidized and removed as iodate, to prevent iodide-induced decomposition of CMCS. This new process provides an efficient and scalable protocol for the preparation of CMCS in 92% solution yield and high purity (>99 GC area %).
Preparation method of methyl bichlorosulfonate
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Paragraph 0011; 0024-0039, (2018/05/16)
The invention discloses a preparation method of methyl bichlorosulfonate. The methyl bichlorosulfonate is prepared through the catalytic addition reaction of fuming sulphuric acid and dichloromethaneunder the condition that boron tribromide is taken as a catalyst. Compared with the prior art, the preparation method of the methyl bichlorosulfonate has the following advantages: (1) the novel catalyst of boron tribromide is cheap and easy to get, and the production cost is lowered; (2) due to the optimized catalyst and reaction condition, the MBCS (Methyl Bichlorosulfonate) yield is increased, and a byproduct CMCS is also reduced; (3) the use of the hazardous difficult-to-treat material sulfur trioxide is avoided, the operability is strong, and the industrial value is high; and (4) the problem of difficulties in storing and fusing the liquid sulfur trioxide in use is avoided.
