142012-67-7

Basic information

• Product Name: 2-fluoro-2-p-methylphenylethanoic acid
• CAS NO: 142012-67-7
• Molecular Weight: 168.168
• Mol File: 142012-67-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-fluoro-2-p-methylphenylethanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-fluoro-2-p-methylphenylethanoic acid(142012-67-7)
• EPA Substance Registry System: 2-fluoro-2-p-methylphenylethanoic acid(142012-67-7)

Safety Data

• Hazardous Substances Data: 142012-67-7(Hazardous Substances Data)

Upstream product

• 5720-05-8 4-methylphenylboronic acid 
• 128839-55-4 ethyl 2-fluoro-2-(4'-methylphenyl)acetate 
• 102862-46-4 3-p-Tolyl-oxirane-2,2-dicarbonitrile 
• 106468-03-5 2-fluoro-2-(4-methylphenyl)ethanenitrile 
• 1026589-67-2 3-Fluoro-2-oxo-3-p-tolyl-propionitrile 
• 13227-01-5 2-amino-2-(4-methylphenyl)acetic acid 
• 104-87-0 4-methyl-benzaldehyde 
• 66985-49-7 2-(4-methylphenyl)-2-(trimethylsilyloxy)acetonitrile 

Downstream Products

• 1379665-29-8 (S)-3-fluoro-1,5-dimethyl-3-(4-methylphenyl)-indolin-2-one 
• 1379665-13-0 N-(2-bromo-5-methylphenyl)-N-methyl-2-fluoro-2-(4-methylphenyl)acetamide 
• 1379664-96-6 C₁₆H₁₅BrFNO 

Relevant articles and documents

Synthesis of 18F-difluoromethylarenes using aryl boronic acids, ethyl bromofluoroacetate and [18F]fluoride

Herein, we report the radiosynthesis of 18F-difluoromethylarenes via the assembly of three components, a boron reagent, ethyl bromofluoroacetate, and cyclotron-produced non-carrier added [18F]fluoride. The two key steps are a copper-catalysed cross-coupling reaction, and a Mn-mediated 18F-fluorodecarboxylation.

Synthesis of 2-fluoro- acids, esters, and amides from α-dicyanoepoxides

The opening of α-dicyanoepoxides by pyridine polyhydrofluoride yields polymerisable 2-fluorocyanoformyls which may be kept intact when diluated in dichloromethane or ether. These intermediates react with nucleophiles such as water, methanol or amines to give respectively 2-fluoroacids, esters or amides.