1420180-99-9

Upstream product

• 1420181-00-5 (5-amino-2-butyl-benzofuran-3-yl)[4'-(3,3-diethoxypropoxy)phenyl]methanone 
• 124-63-0 methanesulfonyl chloride 
• 35573-93-4 3-chloro-1,1-diethoxy-propane 
• 1420181-01-6 (2-butyl-5-nitro-1-benzofuran-3-yl)[4-(3,3-diethoxypropoxy)phenyl]methanone 
• 141645-16-1 2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran 

Downstream Products

• 141626-36-0 dronedarone 
• 1420180-98-8 N-(2-butyl-3-[4-(3-oxopropoxy)benzoyl]-1-benzofuran-5-yl)methanesulfonamide 

Relevant academic research and scientific papers

REDUCTIVE ANIMATION PROCESS FOR PREPARATION OF DRONEDARONE USING ALDEHYDE INTERMEDIARY COMPOUND

The invention relates to a novel process for preparation of dronedarone of formula (I) and pharmaceutically acceptable salts thereof, characterized in that the compound of formula (II) is reacted with dibutylamine of formula (III), under reducing circumstances, and the obtained product is isolated and, if desired, converted into a pharmaceutically acceptable salt thereof, The invention also relates to some novel intermediary compounds and the preparation thereof.