1420271-08-4 Usage
Description
2-Azaspiro[3.3]heptane hydrochloride, also known as spirodelanone or tricyclo[5.2.1.0(2,6)]decane hydrochloride, is a bicyclic chemical compound primarily utilized as a pharmaceutical intermediate. Characterized by its unique spiro backbone, this compound possesses distinctive chemical properties that make it valuable in the synthesis of various pharmaceuticals, especially those targeting the central nervous system (CNS). The hydrochloride salt form enhances its solubility and stability, facilitating its application in pharmaceutical manufacturing processes. Its versatile chemical structure also holds promise for broader applications in medicinal chemistry and drug discovery.
Uses
Used in Pharmaceutical Manufacturing:
2-Azaspiro[3.3]heptane hydrochloride is used as a pharmaceutical intermediate for the synthesis of various CNS drugs. Its unique spiro backbone and improved solubility and stability due to the hydrochloride salt form make it an essential component in the development of medications targeting neurological disorders and conditions.
Used in Medicinal Chemistry and Drug Discovery:
2-Azaspiro[3.3]heptane hydrochloride is utilized as a key building block in medicinal chemistry for the design and synthesis of novel compounds with potential therapeutic applications. Its versatile chemical structure allows for the exploration of new drug candidates, contributing to the advancement of drug discovery efforts in various therapeutic areas.
Check Digit Verification of cas no
The CAS Registry Mumber 1420271-08-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,2,0,2,7 and 1 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1420271-08:
(9*1)+(8*4)+(7*2)+(6*0)+(5*2)+(4*7)+(3*1)+(2*0)+(1*8)=104
104 % 10 = 4
So 1420271-08-4 is a valid CAS Registry Number.
1420271-08-4Relevant articles and documents
Method for mildly preparing 2-azaspiro [3.3] heptane hydrochloride
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Paragraph 0006-0007; 0012, (2021/06/09)
The invention relates to a method for mildly preparing 2-azaspiro [3.3] heptane hydrochloride, and solves the technical problem that in historical literatures, harsh conditions of strong base sodium are needed. The synthesis method comprises the following steps: (1) reducing cyclobutane-1,1-dicarboxylic acid into dimethyl alcohol; (2) reacting the 1, 1-cyclobutane dimethyl carbinol with methanesulfonyl chloride to generate 1,1-cyclobutane dimethyl carbinol dimethyl sulfonate; (3) carrying out ring closing on the 1,1-cyclobutane dimethyl carbinol dimethyl sulfonate and the 2-nitrobenzene sulfonamide to generate 2-(2-nitrobenzenesulfonyl)-2-azaspiro [3.3] heptane; (4) enabling the 2-(2-nitrobenzenesulfonyl)-2-azaspiro [3.3] heptane to react with dodecanethiol under the action of DBU to remove the 2-nitrobenzenesulfonyl so as to generate 2-azaspiro [3.3] heptane; and (5) reacting the 2-azaspiro [3.3] heptane with BOC anhydride to generate Boc-2-azaspiro [3.3] heptane, and then performing treatment with hydrochloric acid to obtain the 2-azaspiro [3.3] heptane hydrochloride. The method is mild and easy to operate, and avoids violent conditions of removing amino protecting groups by strong base at high temperature.
