1259489-92-3 Usage
Uses
Used in Medicinal Chemistry Research:
2-Azaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester is utilized as a structural component in the development of new pharmaceutical compounds. Its unique spiro-connected ring system provides a distinct scaffold that can be modified to explore various biological activities and therapeutic potentials.
Used in Chemical Synthesis:
2-Azaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester serves as an intermediate or a building block in the synthesis of more complex molecules, particularly in the field of organic chemistry. Its reactivity and structural features make it a valuable asset in the creation of novel chemical entities with potential applications in various industries.
Used in Drug Design:
2-Azaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester is employed as a template in drug design, where its structural properties can be leveraged to create new molecules with desired pharmacological properties. Its adaptability in chemical modifications allows for the exploration of different drug candidates with improved efficacy and safety profiles.
Used in Analytical Chemistry:
2-Azaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester can be used as a reference material or a standard in analytical chemistry, particularly in techniques such as chromatography, mass spectrometry, and nuclear magnetic resonance (NMR) spectroscopy. Its well-defined structure and properties make it suitable for calibration and method development in analytical procedures.
Check Digit Verification of cas no
The CAS Registry Mumber 1259489-92-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,5,9,4,8 and 9 respectively; the second part has 2 digits, 9 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1259489-92:
(9*1)+(8*2)+(7*5)+(6*9)+(5*4)+(4*8)+(3*9)+(2*9)+(1*2)=213
213 % 10 = 3
So 1259489-92-3 is a valid CAS Registry Number.
1259489-92-3Relevant academic research and scientific papers
Method for mildly preparing 2-azaspiro [3.3] heptane hydrochloride
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, (2021/06/09)
The invention relates to a method for mildly preparing 2-azaspiro [3.3] heptane hydrochloride, and solves the technical problem that in historical literatures, harsh conditions of strong base sodium are needed. The synthesis method comprises the following steps: (1) reducing cyclobutane-1,1-dicarboxylic acid into dimethyl alcohol; (2) reacting the 1, 1-cyclobutane dimethyl carbinol with methanesulfonyl chloride to generate 1,1-cyclobutane dimethyl carbinol dimethyl sulfonate; (3) carrying out ring closing on the 1,1-cyclobutane dimethyl carbinol dimethyl sulfonate and the 2-nitrobenzene sulfonamide to generate 2-(2-nitrobenzenesulfonyl)-2-azaspiro [3.3] heptane; (4) enabling the 2-(2-nitrobenzenesulfonyl)-2-azaspiro [3.3] heptane to react with dodecanethiol under the action of DBU to remove the 2-nitrobenzenesulfonyl so as to generate 2-azaspiro [3.3] heptane; and (5) reacting the 2-azaspiro [3.3] heptane with BOC anhydride to generate Boc-2-azaspiro [3.3] heptane, and then performing treatment with hydrochloric acid to obtain the 2-azaspiro [3.3] heptane hydrochloride. The method is mild and easy to operate, and avoids violent conditions of removing amino protecting groups by strong base at high temperature.
