1420299-69-9

Upstream product

• 1420299-84-8 [2,6-η6:η1-bis(2,4,6-trimethylphenyl)phenylthiolato]chlorido[tris(4-fluorophenyl)phosphine]ruthenium(II) 
• 79060-88-1 sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate 

Downstream Products

• 1420299-97-3 C₄₂H₃₈F₃PRuS 
• 1420300-01-1 C₈₄H₇₅F₆P₂Ru₂S₂⁽¹⁺⁾*C₃₂H₁₂BF₂₄^(1-) 
• 1420299-89-3 C₅₅H₅₁F₃PRuSSi⁽¹⁺⁾*C₃₂H₁₂BF₂₄^(1-) 

Relevant academic research and scientific papers

C(sp3)-F bond activation of CF3-substituted anilines with catalytically generated silicon cations: Spectroscopic evidence for a hydride-bridged Ru-S dimer in the catalytic cycle

Heterolytic splitting of the Si-H bond mediated by a Ru-S bond forms a sulfur-stabilized silicon cation that is sufficiently electrophilic to abstract fluoride from CF3 groups attached to selected anilines. The ability of the Ru-H complex, generated in the cooperative activation step, to intramolecularly transfer its hydride to the intermediate carbenium ion (stabilized in the form of a cationic thioether complex) is markedly dependent on the electronic nature of its phosphine ligand. An electron-deficient phosphine thwarts the reduction step but, based on the Ru-S catalyst, half of an equivalent of an added alkoxide not only facilitates but also accelerates the catalysis. The intriguing effect is rationalized by the formation of a hydride-bridged Ru-S dimer that was detected by 1H NMR spectroscopy. A refined catalytic cycle is proposed.