142034-75-1Relevant academic research and scientific papers
A concise and efficient synthesis of substituted morpholines
Dugar, Sundeep,Sharma, Amit,Kuila, Bilash,Mahajan, Dinesh,Dwivedi, Sandeep,Tripathi, Vinayak
supporting information, (2015/02/19)
A simple and efficient method has been developed for the synthesis of substituted morpholines by a sequence of coupling, cyclization, and reduction reactions of easily available amino alcohols and α-halo acid chlorides. Various mono-, di-, and trisubstituted morpholines, spiro morpholines, and ring-fused morpholines, as well as morpholine homologues, were synthesized in good to excellent yields by a single methodology under similar reaction conditions. The method was also used in a multigram synthesis of (3S)-3-methylmorpholine.
Chloroacetyl Group Migration in Cyclization of trans-N-Methyl-2-(chloroacetoxy)cyclohexylamine Hydrochloride
Katash, L. S.,Prishchepenko, V. M.,Zhavnerko, K. A.
, p. 831 - 833 (2007/10/03)
Cyclization of trans-N-methyl-2-(chloroacetoxy)cyclohexylamine under the action of alkali is preceded by O--> N migration of the chloroacetyl group with intermediate formation of corresponding chloroacetamide.
Preparation of diastereomerically pure immunologically active carbocyclic nor-muramyldipeptide analogues
Kikelj,Kidric,Pristovisek,Pecar,Urleb,Krbavcic,Honig
, p. 5915 - 5932 (2007/10/02)
The preparation of diastereomerically pure immunologically active carbocyclic nor-muramyldipeptide analogues (1'R,2'R)-/(1'S,2'S)-N-[2-(2'-acetylaminocyclohexyloxy)acetyl]-L- alanyl-D-isoglutamine and (1'R,2'R)-/(1'S,2'S)-N-[2-(2'-acetylaminocyclohexyloxy)acetyl]-L- alanyl-D-glutamic acid is described. The title compounds were synthesized using two independent synthetic routes from racemic trans-2-azidocyclohexanol and (1R,2R)-/(1S,2S)-2-aminocyclohexanol, respectively.
