1420468-51-4

Basic information

• Product Name: 3-(2-methyl-3-(trifluoromethyl)benzyl)-5-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-ol
• Synonyms: 3-(2-methyl-3-(trifluoromethyl)benzyl)-5-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-ol
• CAS NO: 1420468-51-4
• Molecular Weight: 384.361
• Mol File: 1420468-51-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-(2-methyl-3-(trifluoromethyl)benzyl)-5-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-methyl-3-(trifluoromethyl)benzyl)-5-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-ol(1420468-51-4)
• EPA Substance Registry System: 3-(2-methyl-3-(trifluoromethyl)benzyl)-5-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-ol(1420468-51-4)

Safety Data

• Hazardous Substances Data: 1420468-51-4(Hazardous Substances Data)

Upstream product

• 1420468-44-5 3,3-bis(methyloxy)-2-{[2-methyl-3-(trifluoromethyl)phenyl]methyl}propanenitrile 
• 26377-17-3 ethyl 3-oxo-3-(4-pyridyl)propanoate 
• 1420468-45-6 4-{[2-methyl-3-(trifluoromethyl)phenyl]methyl}-1H-pyrazol-3-amine 
• 878001-20-8 2-methyl-3-(trifluoromethyl)benzaldehyde 
• 1420468-43-4 (2E)-2-[bis(methyloxy)methyl]-3-[2-methyl-3-(trifluoromethyl)phenyl]-2-propenenitrile 
• 1420468-31-0 5-methyl-4-[[2-methyl-3-(trifluoromethyl)phenyl]methyl]-1H-pyrazol-3-amine 
• 1420468-30-9 2-{[2-methyl-3-(trifluoromethyl)phenyl]methyl}-3-oxobutanenitrile 
• 261952-16-3 1-(bromomethyl)-2-methyl-3-(trifluoromethyl)benzene 

Relevant articles and documents

Pyrazolopyrimidine derivatives as PI3 kinase inhibitors

PI3Kβ selective compounds having the structure

3a,4-Dihydropyrazolo[1,5 a]pyrimidines: Novel, Potent, and Selective Phosphatidylinositol-3-kinase β Inhibitors

A series of novel [3a,4]dihydropyrazolo[1,5a]pyrimidines were identified, which were highly potent and selective inhibitors of PI3Kβ. The template afforded the opportunity to develop novel SAR for both the hinge-binding (R 3) and back-pocket (R4) substitutents. While cellular potency was relatively modest due to high protein binding, the series displayed low clearance in rat, mouse, and monkey.