1420481-73-7Relevant academic research and scientific papers
C2-symmetric cyclic selenium-catalyzed enantioselective bromoaminocyclization
Chen, Feng,Tan, Chong Kiat,Yeung, Ying-Yeung
, p. 1232 - 1235 (2013/03/28)
A catalytic asymmetric bromocyclization of trisubstituted olefinic amides that uses a C2-symmetric mannitol-derived cyclic selenium catalyst and a stoichiometric amount of N-bromophthalimide is reported. The resulting enantioenriched pyrrolidine products, which contain two stereogenic centers, can undergo rearrangement to yield 2,3-disubstituted piperidines with excellent diastereoselectivity and enantiospecificity.
