142070-83-5Relevant articles and documents
Antibiotic C-3 dithioacetal-substituted carbapenem compounds, compositions, and methods of use thereof
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, (2008/06/13)
A dithioacetal carbapenem of the formula STR1 in which R1 is hydrogen or C1-6 alkyl; n is 0, 1 or 2; R3 is hydrogen or C1-6 alkyl; R2 is C1-6 alkyl, phenyl optionally substituted with cyano, --CO2 NH2, --CH2 OH, --CH2 NH2, --CONHNH2 or with up to 5 halogen atoms, C1-6 alkyl or C1-6 alkyloxy groups, phenylmethyl optionally substituted with up to 5 halogen atoms, C1-6 alkyl or C1-6 alkyloxy groups on the phenyl ring, or a radical represented by the formula in which p is 0 or 1; X is five-membered aromatic heterocyclic ring containing up to 1 sulfur, 1 oxygen or 4 nitrogen atoms, optionally substituted with a C1-6 alkyl group, or six-membered aromatic heterocylic ring containing up to 4 nitrogen atoms, optionally substituted with a C1-6 alkyl group. or a non-toxic pharmaceutically acceptable salt, physiologically hydrolyzable ester or solvate thereof.
