142070-82-4

Upstream product

• 3446-89-7 4-(Methylthio)benzaldehyde 
• 38185-19-2 4-(methylthio)benzyl bromide 
• 874-87-3 1-(chloromethyl)-4-methylthiobenzene 
• 3446-90-0 4-(methylthio)benzyl alcohol 
• 124-63-0 methanesulfonyl chloride 

Downstream Products

• 21382-98-9 p-cyanophenyl methyl sulfide 
• 1233082-98-8 C₂₃H₂₃N₃O₂S 
• 3446-89-7 4-(Methylthio)benzaldehyde 
• 15197-90-7 N,N-dimethyl-1-(4-(methylthio)phenyl)methanamine 
• 84212-03-3 4-(Methylthio)-N-methylbenzenemethanamine 
• 142070-83-5 4-[(chloromethyl)thio]benzylazide 

Relevant academic research and scientific papers

Carcarinic acid-1, 2, 3- based triazole compound as well as preparation method and application thereof (by machine translation)

The method comprises the following steps: firstly 1, 2, 3 - oxidizing and opening the carbon- carbon double bond of the, carcarinic acid into methylene to, obtain carcarinic acid (not shown, in the technical field of, organic 3 - synthesis), Wolf - Kishner - 1, 2, 3 - 1, 2, 3 - 1, 2, 3 - 3 . (by machine translation)

Discovery of Natural Product Derived Labdane Appended Triazoles as Potent Pancreatic Lipase Inhibitors

Obesity contributes to the genesis of many metabolic disorders including dyslipidemia, coronary heart disease (CHD), nonalcoholic fatty liver, type 2 diabetes, etc. Pancreatic lipase plays a vital role in food fat digestion and absorption. Therefore, to c

Selective synthesis of mono- and di-methylated amines using methanol and sodium azide as C1 and N1 sources

A Ru(ii) complex mediated synthesis of various N,N-dimethyl and N-monomethyl amines from organic azides using methanol as a methylating agent is reported. This methodology was successfully applied for a one-pot reaction of bromide derivatives and sodium azide in methanol. Notably, by controlling the reaction time several N-monomethylated and N,N-dimethylated amines were synthesized selectively. The practical applicability of this tandem process was revealed by preparative scale reactions with different organic azides and synthesis of an anti-vertigo drug betahistine. Several kinetic experiments and DFT studies were carried out to understand the mechanism of this transformation.

Synthesis of diaziridines and diazirines via resin-bound sulfonyl oximes

Diazirines are one of the most prominent functionalities in labeling experiments in vivo and in vitro because they allow photochemical generation of carbenes. The strategy presented herein describes the formation of diaziridines, being essential precursors in diazirine syntheses, using solid-supported procedures with immobilized sulfonyl oximes. The solid-supported building blocks have been shown to be valuable intermediates for CuAAC and amidation reactions, offering the possibility to build complex compounds with diverse functionalities.

The Cu(i)-catalysed Huisgen 1,3-dipolar cycloaddition route to (bio-)organic functionalisation of polyoxovanadates

The [V6O13{(OCH2)3CCH2OCH2CCH}2]2- with two terminal alkyne functionalities exhibits excellent reactivity towards (bio-)organic azides. The designed synthetic protocol for the generation of triazol-modified Lindqvist hexavanadates grants access to bio-"clicked" polyoxometalates with spectroscopically detectable 51V nuclei.

An efficient transformation from benzyl or allyl halides to aryl and alkenyl nitriles

(Figure presented) A novel approach to aryl or alkenyl nitriles from benzyl and allyl halides has been developed. A tandem TBAB-catalyzed substitution and the subsequent novel oxidative rearrangement are involved in this transformation. To the best of our knowledge, this is the first transformation from allyl halides to alkenyl nitriles. The broad reaction scope and the mild conditions may make these methods of use in organic synthesis.

Antibiotic C-3 dithioacetal-substituted carbapenem compounds, compositions, and methods of use thereof

A dithioacetal carbapenem of the formula STR1 in which R1 is hydrogen or C1-6 alkyl; n is 0, 1 or 2; R3 is hydrogen or C1-6 alkyl; R2 is C1-6 alkyl, phenyl optionally substituted with cyano, --CO2 NH2, --CH2 OH, --CH2 NH2, --CONHNH2 or with up to 5 halogen atoms, C1-6 alkyl or C1-6 alkyloxy groups, phenylmethyl optionally substituted with up to 5 halogen atoms, C1-6 alkyl or C1-6 alkyloxy groups on the phenyl ring, or a radical represented by the formula in which p is 0 or 1; X is five-membered aromatic heterocyclic ring containing up to 1 sulfur, 1 oxygen or 4 nitrogen atoms, optionally substituted with a C1-6 alkyl group, or six-membered aromatic heterocylic ring containing up to 4 nitrogen atoms, optionally substituted with a C1-6 alkyl group. or a non-toxic pharmaceutically acceptable salt, physiologically hydrolyzable ester or solvate thereof.