142075-85-2

Upstream product

• 109-74-0 propyl cyanide 
• 1519-39-7 (R)-methyl p-tolyl sulfoxide 
• 1540-34-7 3-ethyl-2,4-pentanedione 
• 1517-82-4 (-)-menthyl p-toluenesulfinate 
• 6070-14-0 (-)-menthyl butyrate 
• 105-54-4 butanoic acid ethyl ester 

Downstream Products

• 260560-97-2 (4-Methoxy-phenyl)-[1-((R)-toluene-4-sulfinylmethyl)-but-(E)-ylidene]-amine 
• 142076-00-4 (R)-1-Phenyl-2-((R)-toluene-4-sulfinyl)-hexan-3-ol 
• 142076-01-5 (R)-5-((R)-Toluene-4-sulfinyl)-oct-7-en-4-ol 
• 142075-99-8 (R)-2-((R)-Toluene-4-sulfinyl)-hexan-3-ol 
• 144782-50-3 (1R,(S)R)-N-benzyl-1-n-propyl-2-(p-tolylsulfinyl)ethylamine 
• 144782-53-6 Benzyl-[(S)-1-((R)-toluene-4-sulfinylmethyl)-butyl]-amine 
• 443641-91-6 (R)-(E)-N-benzyl-1-(p-tolylsulfinyl)-2-pentenylamine 
• 142075-86-3 (R_S)-2-<(4-methylphenyl)sulfinyl>hexane 
• 144782-46-7 Benzyl-[1-((R)-toluene-4-sulfinylmethyl)-but-(E)-ylidene]-amine 
• 142075-90-9 5-((R)-Toluene-4-sulfinyl)-oct-7-en-4-one 
• 142075-88-5 1-Phenyl-2-((R)-toluene-4-sulfinyl)-hexan-3-one 

Relevant academic research and scientific papers

A new and general synthesis of chiral β-ketosulfoxides by reaction of (+)-(R)-methyl p-tolyl sulfoxide with nitriles

The nitrile functional group is efficiently transformed into the β-ketosulfoxide moiety by reaction with the anion formed from (+)-(R)-methyl p-tolyl sulfoxide and aqueous acidic work-up of the reaction.

1,3-Asymmetric Induction in the Reduction of α-Alkyl β-Ketosulfoxides with DIBAL/ZnBr2

The highly stereoselective reduction of chiral α-alkyl β-ketosulfoxides with DIBAL/ZnBr2 is governed by the configuration at the sulfur (1,3-induction) and not by that of the C-α (1,2-induction) as it has been previously reported.This fact considerably in

Preparation of Chiral β-Hydroxyketones by Aldol-type Condensation of Chiral p-Tolylsulfinylmethyl Ketones

Chiral β-hydroxyketones 7 with fair e.e. were prepared by treating newly prepared optically pure p-tolylsulfinylmethyl ketones 4 with t-butylmagnesium bromide and aldehydes 5 followed by desulfurization with aluminium amalgam.

The Preparation of Optically Active β-Keto Sulfoxides by Means of an Enantiomer-differentiating Reaction of α-Lithio Aryl Methyl Sulfoxides with Chiral Carboxylates

The reaction of α-lithio aryl methyl sulfoxides with a limited amount of chiral carboxylates (R2-CO-O-R*) was found to be an enantiomer-differentiating reaction, affording the corresponding optically active β-keto sulfoxides (3), tog