142078-08-8Relevant articles and documents
Dual Activation of Unsaturated Amides with Schwartz's Reagent: A Diastereoselective Access to Cyclopentanols and N,O-Dimethylcyclopentylhydroxylamines.
Coelho, Aurélien,Souvenir Zafindrajaona, Mahasoa-Salina,Vallée, Alexis,Behr, Jean-Bernard,Vasse, Jean-Luc
supporting information, (2021/12/06)
The diastereoselective access to cyclopentanols and N,O-dimethylcyclopentylhydroxylamines from 4-pentenoic acid-derived Weinreb amides is described. Based on the concomitant generation of both the nucleophilic and the electrophilic poles by hydrozirconati
Design, synthesis, and biological evaluation of monopyrrolinone-based HIV-1 protease inhibitors
Smith III, Amos B.,Cantin, Louis-David,Pasternak, Alexander,Guise-Zawacki, Lisa,Yao, Wenquin,Charnley, Adam K.,Barbosa, Joseph,Sprengeler, Paul A.,Hirschmann, Ralph,Munshi, Sanjeev,Olsen, David B.,Schleif, William A.,Kuo, Lawrence C.
, p. 1831 - 1844 (2007/10/03)
The design, synthesis, and biological evaluation of a series of HIV-1 protease inhibitors [(-)-6, (-)-7, (-)-23, (+)-24] based upon the 3,5,5-trisubstituted pyrrolin-4-one scaffold is described. Use of a monopyrrolinone scaffold leads to inhibitors with i
Lewis acid promoted asymmetric 1,4-addition of allyltrimethylsilanes to chiral α,β-unsaturated n-acylamides
Wu, Ming-Jung,Wu, Chi-Cheng,Lee, Pei-Chen
, p. 2547 - 2548 (2007/10/02)
The 1,4-addition reaction of allytrimethylsilane to α,unsaturated N-acyloxazolidinones or N-enoylsultams in the presence of Lewis acid proceeds in good chemical yield with high diastereomeric excess. The absolute configuration of the new asymmetric center