85000-04-0Relevant articles and documents
Design, synthesis, and biological evaluation of monopyrrolinone-based HIV-1 protease inhibitors
Smith III, Amos B.,Cantin, Louis-David,Pasternak, Alexander,Guise-Zawacki, Lisa,Yao, Wenquin,Charnley, Adam K.,Barbosa, Joseph,Sprengeler, Paul A.,Hirschmann, Ralph,Munshi, Sanjeev,Olsen, David B.,Schleif, William A.,Kuo, Lawrence C.
, p. 1831 - 1844 (2007/10/03)
The design, synthesis, and biological evaluation of a series of HIV-1 protease inhibitors [(-)-6, (-)-7, (-)-23, (+)-24] based upon the 3,5,5-trisubstituted pyrrolin-4-one scaffold is described. Use of a monopyrrolinone scaffold leads to inhibitors with i
A NEW AND EFFECTIVE ASYMMETRIC SYNTHESIS OF 3-PHENYLALKANALS
Mukaiyama, Teruaki,Hayashi, Hiroki,Miwa, Tetsuo,Narasaka, Koichi
, p. 1637 - 1640 (2007/10/02)
Highly optically active 3-phenylalkanals were obtained by the reaction of alkyl halides and a chiral homoenolate equivalent derived from the cinnamyl ether 3 and potassium diisopropylamide, followed by acidic hydrolysis.
CHIRAL HOMOENOLATE EQUIVALENTS. I. ASYMMETRIC SYNTHESIS OF β-SUBSTITUTED ALDEHIDES VIA METALATED CHIRAL ALLYLAMINES
Ahlbrecht, Hubertus,Bonnet, Gerhard,Enders, Dieter,Zimmermann, Gerd
, p. 3175 - 3178 (2007/10/02)
Metalated chiral allylamines of type 2 (M = Li, K) are used as chiral homoenolate equivalents and allow after alkylation and acidic hydrolysis asymmetric C-C bond formations to β-substituted aldehydes in enantiomeric excesses up to 67percent.