14208-83-4

Basic information

• Product Name: 3-AMINO-ISONICOTINIC ACID ETHYL ESTER
• Synonyms: ETHYL 3-AMINOPYRIDINE-4-CARBOXYLATE;3-AMINOPYRIDINE-4-CARBOXYLIC ACID ETHYL ESTER;3-AMINO-ISONICOTINIC ACID ETHYL ESTER;3-AMINO-4-PYRIDINECARBOXYLIC ACID ETHYL ESTER;Ethyl3-amino-4-pyridinecarboxylate;3-Amino-isonicotinic acid ethyl ester ,98%;Isonicotinic acid, 3-amino-, ethyl ester (8CI);Ethyl 3-aminopyridine-4-carboxylate, 4-(Ethoxycarbonyl)pyridin-3-amine
• CAS NO: 14208-83-4
• Molecular Formula: C₈H₁₀N₂O₂
• Molecular Weight: 166.18
• Product Categories: pharmacetical;Esters;Pyridines;API intermediates;Pyridine;Heterocycle-Pyridine series;Pyrazoles
• Mol File: 14208-83-4.mol
• Article Data: 8

Chemical Properties

• Melting Point: 170-175
• Boiling Point: 303.984 °C at 760 mmHg
• Flash Point: 137.645 °C
• Appearance: /
• Density: 1.193 g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.559
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 4.13±0.18(Predicted)
• CAS DataBase Reference: 3-AMINO-ISONICOTINIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 3-AMINO-ISONICOTINIC ACID ETHYL ESTER(14208-83-4)
• EPA Substance Registry System: 3-AMINO-ISONICOTINIC ACID ETHYL ESTER(14208-83-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39-45
• Hazardous Substances Data: 14208-83-4(Hazardous Substances Data)

Usage

Chemical Properties

Off-white powder or chunks solid

Uses

3-Amino-isonicotinic Acid Ethyl Ester acts as a reagent for the synthetic preparation of heteroaryl compounds as PDE-10 inhibitors useful in treatment and prevention of CNS, metabolic and other diseases. Also in the design and evaluation of 1,7-naphthyridones as novel KDM5 inhibitors.

InChI:InChI=1/C8H10N2O2/c1-2-12-8(11)6-3-4-10-5-7(6)9/h3-5H,2,9H2,1H3

Upstream product

• 490-11-9 3,4-pyridinecarboxylic acid 
• 7579-20-6 3-Aminopyridine-4-carboxylic acid 
• 4664-01-1 3,4-pyridinedicarboximide 
• 64-17-5 ethanol 

Downstream Products

• 64189-08-8 3-Aminopyridin-4-carboxysaeurehydrazid 
• 157361-40-5 ethyl 3-allylaminopyridine-4-carboxylate 
• 152398-05-5 (3-amino-pyridin-4-yl)methanol 
• 18342-97-7 ethyl 3-hydroxyisonicotinate 
• 1093759-41-1 ethyl 3-amino-2-chloroisonicotinate 
• 343-72-6 ethyl 3-fluoroisonicotinate 
• 862314-10-1 ethyl 5-amino-2-chloroisonicotinate 
• 1461601-04-6 3-[(3-phenylpropanoyl)amino]-4-pyridinecarboxylic acid 
• 1461601-05-7 3-[(phenylcarbonyl)amino]-4-pyridinecarboxylic acid 
• 1461603-03-1 ethyl 3-[(phenylcarbonyl)amino]-4-pyridinecarboxylate 
• 16081-85-9 2-phenylpyrido[3,4-d]pyrimidin-4(3H)-one 
• 1461602-98-1 ethyl 3-{[(4-chlorophenyl)acetyl]amino}-4-pyridinecarboxylate 
• 1461603-23-5 ethyl 3-[(3-phenylpropyl)amino]-4-pyridinecarboxylate 
• 1461603-34-8 ethyl 3-[(3-{[3-(trifluoromethyl)phenyl]oxy}propyl)amino]-4-pyridinecarboxylate 

Relevant articles and documents

TRICYCLIC HETEROARYL COMPOUNDS USEFUL AS IRAK4 INHIBITORS

Disclosed are compounds of Formula (I) or a salt or prodrug thereof, wherein: X11 and X22 are independently C or N, provided that zero or one of X11 and X22 is N; Ring A represented by the structure is: or; and Q, R11, R22, R33, R44, R66, and p are define herein. Also disclosed are methods of using such compounds as modulators of IRAK4, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing inflammatory and autoimmune diseases, or in the treatment of cancer.

AROMATIC SULFONE COMPOUND AS ALDOSTERONE RECEPTOR MODULATOR

The present invention provides a compound represented by the following formula (I): [wherein, A represents a group of the following formula (A-1): etc., R1 and R2 each independently represent a hydrogen atom etc., Z represents CR3 etc., W represents CR4 etc., Q represents CR5 etc., R3, R4 and R5 each independently represent a hydrogen atom etc., Y represents an oxygen atom or sulfur atom, X represents an oxygen atom etc. and B represents an optionally substituted aryl group or optionally substituted heteroaryl group], the prodrug thereof or the pharmaceutically acceptable salt thereof for preventing or treating various diseases such as hypertesion, cerebral stroke, cardiac failure, etc.

Angiotensin II receptor antagonists

Compounds are disclosed having the formula: STR1 The compounds of the invention are angiotensin II receptor antagonists.