1420998-43-1

Basic information

• Product Name: 2-Methoxy-4-Methyl-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridine
• Synonyms: 2-Methoxy-4-Methyl-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridine;(2-METHOXY-4-METHYLPYRIDIN-3-YL)BORONIC ACID PINACOL ESTER
• CAS NO: 1420998-43-1
• Molecular Formula: C13H20BNO3
• Molecular Weight: 249.1138
• Mol File: 1420998-43-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 355.1±42.0 °C(Predicted)
• Appearance: /
• Density: 1.05±0.1 g/cm3(Predicted)
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 4.04±0.20(Predicted)
• CAS DataBase Reference: 2-Methoxy-4-Methyl-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methoxy-4-Methyl-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridine(1420998-43-1)
• EPA Substance Registry System: 2-Methoxy-4-Methyl-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridine(1420998-43-1)

Safety Data

• Hazardous Substances Data: 1420998-43-1(Hazardous Substances Data)

Usage

General Description

2-Methoxy-4-Methyl-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridine is a chemical compound used in various applications such as in the field of chemistry, medicine, and pharmaceutical industry. It is a pyridine derivative containing a boron substituent, and its structure includes a boron atom bound to an oxygen atom and two methyl groups, as well as a pyridine ring with a methoxy and methyl group attached. 2-Methoxy-4-Methyl-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridine is known for its ability to form complexes with metals, and it is used as a ligand in coordination chemistry. It also has potential applications in organic synthesis and as a reagent in chemical reactions. Overall, 2-Methoxy-4-Methyl-3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridine is a versatile compound with diverse uses in various scientific and industrial fields.

Upstream product

• 717843-51-1 3-bromo-2-methoxy-4-methyl-pyridine 
• 73183-34-3 bis(pinacol)diborane 
• 18368-59-7 3-bromo-2-hydroxy-4-methylpyridine 
• 13466-41-6 2-hydroksy-4-methyl-pyridine 
• 695-34-1 2-Amino-4-methylpyridine 

Relevant articles and documents

FLUORINATED QUINOLINE AND QUINOXALINE DERIVATIVES AS DIHYDROOROTATE DEHYDROGENASE (DHODH) INHIBITORS FOR THE TREATMENT OF CANCER, AUTOIMMUNE AND INFLAMMATORY DISEASES

The present invention discloses compounds formula (I): (I) wherein X is CH; The present compounds of formula (I) are dihydroorotate dehydrogenase (DHODH) inhibitors, and are useful for the treatment of inflammatory disorders, autoimmune disorders and cancer, such as e.g. lymphomas, leukemias, carcinomas, and sarcomas. The present description discloses the synthesis and characterisation of exemplary compounds as well as pharmacological data thereof (e.g. pages 60 to 136; examples 1 to 39; tables 1 and 2). An exemplary compound is e.g. : 4-ethyl-1-(7-fluoro-4-isopropyl-2- (2-methoxyphenyl)quinolin-6-yl)-3-(hydroxymethyl)-1H-1,2,4- triazol-5(4H)-one (example 1): (AA)

OXAZOLE AND THIAZOLE DERIVATIVES AS SELECTIVE PROTEIN KINASE INHIBITORS (C-KIT)

The present invention relates to compounds of formula I or pharmaceutically acceptable salts thereof: wherein R1, R2, R3, A, Q, W and X are as defined in the description. These compounds selectively modulate, regulate, and/or inhibit signal transduction mediated by certain native and/or mutant proteine kinases implicated in a variety of human and animal diseases such as cell proliferative, metabolic, allergic, and degenerative disorders. More particularly, these compounds are potent and selective native and/or mutant c-kit inhibitors.