18368-59-7

Usage

Uses

Used in Pharmaceutical Industry:
2-Hydroxy-3-bromo-4-methylpyridine is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its functional groups allow for the creation of new molecules with potential therapeutic applications.
Used in Chemical Research:
In the field of chemical research, 2-Hydroxy-3-bromo-4-methylpyridine is used as a starting material for the development of new chemical reactions and the exploration of reaction mechanisms. Its versatility in participating in different types of reactions makes it a valuable tool for researchers.
Used in Agrochemical Industry:
2-Hydroxy-3-bromo-4-methylpyridine is used as a precursor in the synthesis of agrochemicals, such as pesticides and herbicides. Its functional groups can be modified to create new compounds with improved efficacy and selectivity in controlling pests and weeds.
Used in Material Science:
In material science, 2-Hydroxy-3-bromo-4-methylpyridine is used as a building block for the development of new materials with specific properties, such as improved thermal stability or enhanced electrical conductivity. Its functional groups can be incorporated into polymers or other materials to achieve desired characteristics.

InChI:InChI=1/C6H6BrNO/c1-4-2-3-8-6(9)5(4)7/h2-3H,1H3,(H,8,9)

Upstream product

• 89581-53-3 3,5-dibromo-2-hydroxy-4-methylpyridine 
• 695-34-1 2-Amino-4-methylpyridine 
• 13466-41-6 2-hydroksy-4-methyl-pyridine 
• 55404-31-4 3-bromo-2-chloro-4-methylpyridine 

Downstream Products

• 1001906-15-5 3-iodo-4-methyl-1-(3-(trifluoromethoxy)phenyl)pyridin-2(1H)-one 
• 1420998-43-1 2-methoxy-4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine 

Relevant academic research and scientific papers

PYRAZOLO[3,4-B]PYRIDINES AND IMIDAZO[1,5-B]PYRIDAZINES AS PDE1 INHIBITORS

The present invention provides compounds of formula (I) that are PDEl enzyme inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative disorders and psychiatric disorders. The present invention also provides pharmaceutical compositions comprising compounds of the invention and methods of treating disorders using the compounds of the invention.

OXAZOLE AND THIAZOLE DERIVATIVES AS SELECTIVE PROTEIN KINASE INHIBITORS (C-KIT)

The present invention relates to compounds of formula I or pharmaceutically acceptable salts thereof: wherein R1, R2, R3, A, Q, W and X are as defined in the description. These compounds selectively modulate, regulate, and/or inhibit signal transduction mediated by certain native and/or mutant proteine kinases implicated in a variety of human and animal diseases such as cell proliferative, metabolic, allergic, and degenerative disorders. More particularly, these compounds are potent and selective native and/or mutant c-kit inhibitors.

SUBSTITUTED PYRIDONE COMPOUNDS AND METHODS OF USE

The present invention comprises a new class of compounds capable of modulating the c-kit receptor and, accordingly, useful for treatment of c-kit mediated diseases, including various inflammatory, fibrotic and/or mast cell mediated diseases such as mastocytosis. The compounds have a general Formula: (I); wherein A0-3 and R1-6 are defined herein. The invention further comprises pharmaceutical compositions, methods for treatment of c-kit mediated diseases, and intermediates and processes useful for the preparation of compounds of the invention.

ALKYNE-SUBSTITUTED PYRIDONE COMPOUNDS AND METHODS OF USE

The present invention comprises a new class of compounds capable of modulating the c-kit receptor and, accordingly, useful for treatment of c-kit mediated diseases, including various inflammatory, fibrotic and/or mast cell mediated diseases such as mastocytosis. The compounds have a general Formula I "INSERT STRUCTURE HERE" wherein A1-3, R1 and R3-6 are defined herein. The invention further comprises pharmaceutical compositions, methods for treatment of c-kit mediated diseases, and intermediates and processes useful for the preparation of compounds of the invention.

Efficient regioselective preparation of monobromo and bromoiodo hydroxy pyridines from dibromoderivatives via bromine-lithium exchange

Annular dibromination of hydroxypyridines with NBS in acetonitrile followed by bromine-lithium exchange with RLi and subsequent trapping with H2O or I2 afforded monobromo and bromoiodo derivatives in a completely regioselective way. Iodination of bromo hydroxypyridines with NIS is totally regioselective.