18368-59-7

Basic information

• Product Name: 2-Hydroxy-3-bromo-4-methylpyridine
• Synonyms: 2-HYDROXY-3-BROMO-4-PICOLINE;2-Hydroxy-3-bromo-4-methylpyridine;3-Bromo-2-hydroxy-4-picoline;3-BroMo-4-Methylpyridin-2-ol;3-BroMo-4-Methylpyridin-2(1H)-one;3-BROMO-4-METHYL-2(1H)-PYRIDINONE;3-Bromo-2-hydroxy-4-methylpyridine
• CAS NO: 18368-59-7
• Molecular Formula: C₆H₆BrNO
• Molecular Weight: 188.02
• Product Categories: Pyridine
• Mol File: 18368-59-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 323.221oC at 760 mmHg
• Flash Point: 149.279oC
• Appearance: /
• Density: 1.622g/cm3
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.574
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 10.56±0.10(Predicted)
• CAS DataBase Reference: 2-Hydroxy-3-bromo-4-methylpyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Hydroxy-3-bromo-4-methylpyridine(18368-59-7)
• EPA Substance Registry System: 2-Hydroxy-3-bromo-4-methylpyridine(18368-59-7)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 18368-59-7(Hazardous Substances Data)

Usage

General Description

2-Hydroxy-3-bromo-4-methylpyridine is an organic compound that features in the group of pyridines and substituted pyridines. Often present as a colorless or slightly yellow liquid, it contains three functional groups: a bromo group, a methyl group, and a hydroxyl group. These functional groups can participate in a variety of chemical reactions, allowing this compound to serve as a versatile intermediate in the synthesis of a range of products. It is generally stored in a cool, dry place, away from heat sources and incompatible materials for safety. While handling this chemical, it's necessary to take precautions as it can cause skin and eye irritation, and prolonged exposure can lead to harm. The safety data sheets must be referred to before handling this chemical.

InChI:InChI=1/C6H6BrNO/c1-4-2-3-8-6(9)5(4)7/h2-3H,1H3,(H,8,9)

Upstream product

• 695-34-1 2-Amino-4-methylpyridine 
• 13466-41-6 2-hydroksy-4-methyl-pyridine 
• 89581-53-3 3,5-dibromo-2-hydroxy-4-methylpyridine 
• 55404-31-4 3-bromo-2-chloro-4-methylpyridine 

Downstream Products

• 1001906-15-5 3-iodo-4-methyl-1-(3-(trifluoromethoxy)phenyl)pyridin-2(1H)-one 
• 1420998-43-1 2-methoxy-4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine 

Relevant articles and documents

PYRAZOLO[3,4-B]PYRIDINES AND IMIDAZO[1,5-B]PYRIDAZINES AS PDE1 INHIBITORS

The present invention provides compounds of formula (I) that are PDEl enzyme inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative disorders and psychiatric disorders. The present invention also provides pharmaceutical compositions comprising compounds of the invention and methods of treating disorders using the compounds of the invention.

SUBSTITUTED PYRIDONE COMPOUNDS AND METHODS OF USE

The present invention comprises a new class of compounds capable of modulating the c-kit receptor and, accordingly, useful for treatment of c-kit mediated diseases, including various inflammatory, fibrotic and/or mast cell mediated diseases such as mastocytosis. The compounds have a general Formula: (I); wherein A0-3 and R1-6 are defined herein. The invention further comprises pharmaceutical compositions, methods for treatment of c-kit mediated diseases, and intermediates and processes useful for the preparation of compounds of the invention.

Efficient regioselective preparation of monobromo and bromoiodo hydroxy pyridines from dibromoderivatives via bromine-lithium exchange

Annular dibromination of hydroxypyridines with NBS in acetonitrile followed by bromine-lithium exchange with RLi and subsequent trapping with H2O or I2 afforded monobromo and bromoiodo derivatives in a completely regioselective way. Iodination of bromo hydroxypyridines with NIS is totally regioselective.