1421-86-9

Basic information

• Product Name: STRYCHNINE HYDROCHLORIDE
• Synonyms: Strychnine Hydrochloride Hydrate;Strychnidin-10-one, monohydrochloride (9ci);Strychnidin-10-onehydrochloride;STRYCHNINE HCL;STRYCHNINE HYDROCHLORIDE;strychnidin-10-one,monohydrochloride;strychnine,monohydrochloride;(4aR,5aS,8aR,13aS,15aS,15bR)-4a,5,5a,7,8,13a,15,15a,15b,16-decahydro-2H-4,6-methanoindolo[3,2,1-ij]oxepino[2,3,4-de]pyrrolo[2,3-h]quinoline-14-one:hydrochloride
• CAS NO: 1421-86-9
• Molecular Formula: C₂₁H₂₂N₂O₂*ClH
• Molecular Weight: 370.87
• EINECS: 215-826-9
• Product Categories: chiral;Alkaloids;Biochemistry;for Resolution of Acids;Indole Alkaloids;Optical Resolution;Synthetic Organic Chemistry;GABA and Glycine Receptor ModulatorsNeurotransmission;Glycinergics;Ion Channels;Ligand-Gated Ion Channels;Neurotransmitters
• Mol File: 1421-86-9.mol
• Article Data: 1

Chemical Properties

• Melting Point: 295 °C
• Boiling Point: 578.8 °C at 760 mmHg
• Flash Point: 303.8 °C
• Appearance: /
• Vapor Pressure: 1.44E-12mmHg at 25°C
• Storage Temp.: Store at RT
• Merck: 14,8855
• CAS DataBase Reference: STRYCHNINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: STRYCHNINE HYDROCHLORIDE(1421-86-9)
• EPA Substance Registry System: STRYCHNINE HYDROCHLORIDE(1421-86-9)

Safety Data

• Hazard Codes: T+,N
• Statements: 26/27/28-51/53-50/53-26/28
• Safety Statements: 22-36/37/39-45-61-60-28-13
• RIDADR: UN 1692 6.1/PG 1
• WGK Germany: 3
• RTECS: WL2430000
• HazardClass: 6.1(a)
• PackingGroup: I
• Hazardous Substances Data: 1421-86-9(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 1421-86-9 differently. You can refer to the following data:
1. Strychnine Hydrochloride acts as an antagonist for cholinesterases and beta amyloid aggregation.
2. Strychnine hydrochloride has been used as a glycine receptor antagonist in the retina for biophysiological functions. It has also been used to block glutamatergic, GABAergic and glycinergic receptors and gap junctions.

Definition

ChEBI: A hydrochloride obtained by combining strychnine with one molar equivalent of hydrogen chloride.

Biological Activity

Competitive glycine receptor antagonist; convulsant. Also nicotinic receptor antagonist; displays competitive antagonism at α 7 receptors and non-competitive antagonism at α 4 β 2 receptors.

Biochem/physiol Actions

Strychnine is a potent convulsant, which is extracted from Strychnos nux vomica seeds. At high doses, the compound causes convulsions and ultimately death due to respiratory paralysis. Strychnine acts as a respiratory, circulatory and digestive stimulant.

InChI:InChI=1/C21H22N2O2.ClH/c24-18-10-16-19-13-9-17-21(6-7-22(17)11-12(13)5-8-25-16)14-3-1-2-4-15(14)23(18)20(19)21;/h1-5,13,16-17,19-20H,6-11H2;1H/t13-,16-,17-,19?,20-,21+;/m0./s1

Synthetic route

strychnidin-10-one (57-24-9) → strychnine hydrochloride (1421-86-9)

Conditions	Yield
With hydrogenchloride In ethyl acetate

mercury(II) cyanide (592-04-1) + strychnine hydrochloride (1421-86-9) → Strychniniumchlorid * Hg(CN)2

Conditions	Yield
In not given in hot dild. soln.; washing with H2O and alcohol, drying at 100°C;

mercury(II) cyanide (592-04-1) + strychnine hydrochloride (1421-86-9) → Strychniniumchlorid * 4Hg(CN)2

Conditions	Yield
In water hot soln.; cooling;
In water

silverdioxalatodimethylethylenediaminechromate(III) * H2O + strychnine hydrochloride (1421-86-9) → strychniniumdioxalatodimethylethylenediaminechromate(III)

Conditions	Yield
In water heating Ag(Cr(C2O4)2(CH3NHC2H4NHCH3)*H2O with H2O and strychninium chloride on water bath with frequent shaking, until soln. is free ofCl(1-), storing filtered soln. for several days;; pptn.;

potassiumdioxalatodipyridinechromate(III) * 3 H2O + strychnine hydrochloride (1421-86-9) → strychniniumdioxalatodipyridinechromate(III)

Conditions	Yield
In water prepn. from aq. solns. of strychninium chloride and K(Cr(C2O4)2(C5H5N)2)*3H2O;;

Upstream product

• 57-24-9 strychnidin-10-one 

Related news

Original ArticleEffect of STRYCHNINE HYDROCHLORIDE (cas 1421-86-9) on liver cytochrome P450 mRNA expression and monooxygenase activities in rat09/24/2019

Strychnos nux-vomica L. has been frequently used in traditional Chinese medicine but has high acute toxicity. It is commonly taken with Glycyrrhizae radix to decrease its toxicity but the mechanism of this interaction is unknown. In this work, the mRNA expression and the activity of four cytochr...detailed

Relevant articles and documents

Structural and chiroptical analysis of naturally occurring (-)-strychnine

Structural aspects such as chemical exchange, dimerization, solvent association, nitrogen inversion and protonation status of strychnine were investigated using experimental and calculated data. The information was mainly interpreted in view of a successful determination of the absolute configuration (AC) with strychnine (base and salt) as test molecule due to its importance in chemistry. By geometry optimization a stable isomer of protonated strychnine was found with an inverted nitrogen, however, 25 kcal/mol higher in energy. It is shown that solvent association can be assumed in protic solvents such as methanol and dimerization to a small extent in polar/protic solvents. However, the monomeric structural model neglecting explicit solvent molecules still allows the correct prediction of the AC of base and hydrochloride using optical rotation and ECD data.