14210-81-2

Basic information

• Product Name: 1H-TETRAZOLE, 1-(4-FLUOROPHENYL)-
• Synonyms: 1H-TETRAZOLE, 1-(4-FLUOROPHENYL)-
• CAS NO: 14210-81-2
• Molecular Formula: C₇H₅FN₄
• Molecular Weight: 164.14
• Mol File: 14210-81-2.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-TETRAZOLE, 1-(4-FLUOROPHENYL)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-TETRAZOLE, 1-(4-FLUOROPHENYL)-(14210-81-2)
• EPA Substance Registry System: 1H-TETRAZOLE, 1-(4-FLUOROPHENYL)-(14210-81-2)

Safety Data

• Hazardous Substances Data: 14210-81-2(Hazardous Substances Data)

Upstream product

• 371-40-4 4-fluoroaniline 
• 149-73-5 trimethyl orthoformate 
• 1374634-43-1 5-[chloro(nitro)methyl]-1-(4-fluorophenyl)-1H-tetrazole 
• 1374634-34-0 1-(1H-benzotriazol-1-yl)-2-chloro-1-[(4-fluorophenyl)imino]-2-nitroethane 
• 1895-39-2 sodium chlorodifluoroacetate 
• 122-51-0 orthoformic acid triethyl ester 

Downstream Products

• 366-75-6 N-(4-fluorophenyl)benzamide 
• 30895-14-8 1-(4-fluorophenyl)-1H-tetrazol-5-amine 
• 1449516-89-5 C₁₅H₁₀BrFN₂ 
• 59541-83-2 5-fluoro-2-phenyl-1H-indole 

Relevant articles and documents

A novel synthesis of 1-aryl tetrazoles promoted by employing the synergy of the combined use of DMSO and an ionic liquid as the solvent system at ambient temperature

The synergy of the combined use of DMSO and an ionic liquid viz. (bbim)+Br- has brought about a mild, convenient, efficient, and rapid protocol for the synthesis of 1-substituted-1H-1,2,3,4-tetrazoles via the condensation of amines, triethyl orthoformate, and sodium azide at ambient temperature in excellent isolated yields (85-90%). The inherent Bronsted acidity of ionic liquid and high polarity of both IL and DMSO resulted in a significant enhancement in the reaction rate.

[3+1+1] type cyclization of ClCF2COONa for the assembly of imidazoles and tetrazolesvia in situgenerated isocyanides

A facile synthesis of imidazoles and tetrazolesvia[3+1+1] type cyclization of ClCF2COONa is developed. A diverse array of imidazoles and tetrazoles were obtained in decent yieldsviaisocyanide intermediates. Notably, this is the first example of the cycloaddition ofin situgenerated isocyanides.

A stereocontrolled 1,2-addition reaction of tetrazoles with alkyl propiolates for the synthesis of highly functionalized enamines

A stereocontrolled 1,2-addition reaction of 1-aryl-1H-tetrazoles with alkyl propiolates for the synthesis of highly functionalized enamines was developed. In the presence of silver oxide (Ag2O), the 1,2-addition reaction generated (Z)-N-cyano enamines in good yields with exclusive formation of the Z-isomers. Meanwhile, the 1,2-addition reaction generated (E)-N-cyano enamines in the presence of Ag2O and potassium carbonate (K2CO 3) with high stereoselectivity and yields. Copyright