1421054-59-2

Upstream product

• 1421054-55-8 ((2S,4R,6R)-4-acrylamido-6-phenyltetrahydro-2H-pyran-2-yl)methyl-4-methylbenzenesulfonate 
• 1421054-56-9 N-((2S,4R,6R)-2-(iodomethyl)-6-phenyltetrahydro-2H-pyran-4-yl)acrylamide 
• 1421054-57-0 N-((1R,3S)-1-hydroxy-1-phenylhex-5-en-3-yl)acrylamide 
• 1421054-58-1 N-((1R,3S)-1-((tert-butyldimethylsilyl)oxy)-1-phenylhex-5-en-3-yl)acrylamide 
• 100-52-7 benzaldehyde 

Downstream Products

• 1421054-60-5 (S)-6-((R)-2-((tert-butyldimethylsilyl)oxy)-2-phenylethyl)piperidin-2-one 
• 495-47-6 1-phenyl-2-[(2S)-piperidin-2-yl]-(1R)-ethan-1-ol 
• 1421054-61-6 (S)-6-((R)-2-hydroxy-2-phenylethyl)piperidin-2-one 

Relevant academic research and scientific papers

Stereoselective synthesis of 2-(2-hydroxyalkyl)piperidine alkaloids through prins-ritter reaction

A stereoselective total synthesis of the 2-(2-hydroxyalkyl)piperidine alkaloids has been accomplished by a Prins-Ritter amidation sequence. Other steps involved in this synthesis are Jacobsen's hydrolytic kinetic resolution (HRK) and ring-closing metathes

Stereoselective synthesis of anti-1,3-aminoalcohols via reductive opening of 4-amidotetrahydropyrans derived from the Prins/Ritter sequence

A novel method has been devised for anti-1,3-aminoalcohols through reductive elimination of iodomethyltetrahydropyrans which are in turn derived from a Prins/Ritter reaction sequence. The synthetic versatility of this method has been explored in the total