142114-68-9Relevant academic research and scientific papers
NOVEL INHIBITOR COMPOUNDS OF PHOSPHODIESTERASE TYPE 10A
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, (2013/02/28)
The present invention relates to novel carboxamide compounds, pharmaceutical compositions containing them, and their use in therapy. The compounds possess valuable therapeutic properties and are particularly suitable for treating or controlling medical disorders selected from neurological disorders and psychiatric disorders, for ameliorating the symptoms associated with such disorders and for reducing the risk of such disorders
An approach to pyrimidine N-oxides: Carboxamide oximes as precursors
Mlakar, Biserka,?tefane, Bogdan,Ko?evar, Marijan,Polanc, Slovenko
, p. 961 - 973 (2007/10/03)
A method for the synthesis of pyrimidines N-oxides is described. Various carboxamide oximes were treated with the appropriate 1,3-dicarbonyl compounds or their equivalents in the presence of trifluoroacetic acid as a catalyst to give the corresponding pyr
The synthesis of pyrimidine 1-oxides: A new transformation of amide oximes
Kocevar,Mlakar,Perdih,Petric,Polanc,Vercek
, p. 2195 - 2198 (2007/10/02)
The title N-oxides were prepared from several carboxamide oximes on treatment with 1,3-dicarbonyl derivatives.
OXIDATION OF 2,4-DISUBSTITUTED PYRIMIDINES WITH ORGANIC PERACIDS
Yamanaka, Hiroshi,Ogawa, Shigeru,Sakamoto, Takao
, p. 573 - 576 (2007/10/02)
While 4,6-disubstituted (alkyl, aryl, alkoxyl) pyrimidines easily afforded the corresponding mono-N-oxides with hydrogen peroxide in glacial acetic acid, pyrimidine derivatives whose 6-position is free, are partly oxidatively degradated during N-oxidation reaction.The oxidation of the latter compounds under the above conditions gave 2,4-disubstituted imidazoles together with their mono-N-oxides.A likely mechanism of this ring-contraction and the improved conditions for the synthesis of the N-oxides are also described.
