14212-98-7

Basic information

• Product Name: phenyl bis(chloromethyl)phosphinate
• Synonyms: PHENYL BIS(CHLOROMETHYL) PHOSPHINATE
• CAS NO: 14212-98-7
• Molecular Formula: C₈H₉Cl₂O₂P
• Molecular Weight: 239.0356
• Mol File: 14212-98-7.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 300.6°C at 760 mmHg
• Flash Point: 174.9°C
• Density: 1.351g/cm³
• Vapor Pressure: 0.00198mmHg at 25°C
• Refractive Index: 1.524
• CAS DataBase Reference: phenyl bis(chloromethyl)phosphinate(CAS DataBase Reference)
• NIST Chemistry Reference: phenyl bis(chloromethyl)phosphinate(14212-98-7)
• EPA Substance Registry System: phenyl bis(chloromethyl)phosphinate(14212-98-7)

Safety Data

• Hazardous Substances Data: 14212-98-7(Hazardous Substances Data)

Upstream product

• 13482-64-9 bis(chloromethyl)phosphinic chloride 
• 1529-17-5 phenyltrimethylsilyl ether 
• 33714-89-5 4-nitrophenyl bis(chloromethyl)phosphinate 
• 108-95-2 phenol 
• 622-46-8 carbamic acid phenyl ester 

Downstream Products

• 87517-96-2 trans-Phenyl <2-(4-nitrophenyl)ethenyl>(chloromethyl)phosphinate 
• 87517-95-1 cis-Phenyl <2-(4-nitrophenyl)ethenyl>(chloromethyl)phosphinate 
• 80991-34-0 (S)-Phenyl (3,4-dioctadecoxybutyl)<(diethoxyphosphinyl)methyl>phosphinate 
• 87517-94-0 (R)-Phenyl (3,4-dioctadecoxybut-1-enyl)(chloromethyl)phosphinate 
• 908809-02-9 [(3,4-Bis-octadecyloxy-butyl)-phenoxy-phosphinoylmethyl]-phosphonic acid 
• 344601-18-9 Chloromethyl-[(triphenyl-λ⁵-phosphanylidene)-methyl]-phosphinic acid phenyl ester 
• 13274-83-4 di(chloromethyl)phosphinic acid 
• 108-95-2 phenol 
• 87517-93-9 Phenyl (chloromethyl)(triphenylphosphoniomethyl)phosphinate chloride 
• 16165-65-4 Bis-dimethylaminomethyl-phosphinic acid phenyl ester 
• 17052-19-6 phenyl bis(iodomethyl)phosphinate 

Relevant articles and documents

Synthesis of azaphosphacyclanes on the basis of reactions of α-aminoalkylphosphonates with bis(chloromethyl)isocyanatophosphinate

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Reactions of α-aminoalkylphosphonates with iso(thio) cyanatophosphates(phosphonates, phosphinates). Synthesis of 1,3,4- diazaphospholidines and 1,3,4-oxaza(thiaza)phospholines

Phenyl α-aminoalkylphosphonates add to phenyl iso(thio)cyanates to give saturated heterocycles, 1,3,4-diazaphospholidin-2-(thi)ones. The reaction of diphenyl (α-methylamino)benzylphosphonate with diethyl isothiocyanatophosphate involves initial formation of 1,3,4-tiazaphospholidine- 2-thiones containing exo- and endocyclic phosphorus atoms. These products are readily hydrolyzed in air, yielding diethyl isothiocyanatophosphate and phenyl hydrogen (α-methylamino)benzylphosphonate. The final products of the reaction of chloromethyl isocyanatophosphonates with aminoalkylphosphonates are 1,3,4-oxazaphospholines. Phenyl aminoalkylphosphonates react with chloromethyl isocyanatophosphonates to give saturated heterocycles, 1,3,4- diazaphospholidines, whereas with chloromethyl isothiocyanatophosphonates 1,3,4-thiazaphospholines are formed.

Reaction of (chloromethyl)phosphonic(-phosphinic) chlorides with silylated protic nucleophiles

Reactions of (chloromethyl)phosphonic(-hosphinic) chlorides with trimethylalkoxy(-phenoxy, -dialkylamino)silanes are accompanied by elimination of trimethylchlorosilane and lead to formation of related substitution products. Reactions of bis(chloromethyl)phosphinic chloride and (chloromethyl)phosphinic dichloride with neutral and hydrogen silyl phosphites were studied. The reactions of bis(chloromethyl)phosphinic chloride with tris(trimethylsilyl)phosphite, diethyl trimethylsilyl phosphite, and bis(trimethylsilyl) hydrogen phosphite yield trimethylsilyl bis(chloromethyl)phosphinate. Similar reactions with (chloromethyl)phosphonic dichloride resulted in isolation of bis(trimethylsilyl) (chloromethyl)phosphonate.