142121-48-0

Usage

Uses

Used in Pharmaceutical Industry:
BOC-D-LEUCINOL 97 is used as a key intermediate in the synthesis of peptide and protein-based pharmaceuticals for its ability to protect the amino group during the synthesis process, allowing for the creation of complex bioactive compounds with specific therapeutic properties.
Used in Research and Development:
In research settings, BOC-D-LEUCINOL 97 serves as a valuable tool for the development of novel peptide and protein structures, contributing to advancements in medical and scientific fields through its role in the synthesis of potential new drugs and therapeutic agents.

Upstream product

• 16369-17-8 2-amino-4-methylpentan-1-ol 
• 24424-99-5 di-tert-butyl dicarbonate 
• 117049-08-8 (1R,2S,5R)-2-(1-methyl-1-phenylethyl)-5-methylcyclohexyl<(tert-butoxycarbonyl)amino>bromoacetate 
• 117681-86-4 (1R,2S,5R)-2-(1-methyl-1-phenylethyl)-5-methylcyclohexyl (tert-butoxycarbonyl)aminoacetate 
• 4530-20-5 BOC-glycine 
• 117049-12-4 2-tert-Butoxycarbonylamino-4-methyl-pentanoic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester 

Downstream Products

• 13139-15-6 Boc-DL-Leu-OH 

Relevant academic research and scientific papers

GLYCINE TRANSPORTER-INHIBITING SUBSTANCES

The present invention relates to novel compounds of formula [I] or pharmaceutically acceptable salts thereof: The compounds of the present invention are useful in the prevention or treatment of diseases such as schizophrenia, Alzheimer's disease, cognitive impairment, dementia, anxiety disorders (e.g., generalized anxiety disorder, panic disorder, obsessive-compulsive disorder, social anxiety disorder, post-traumatic stress disorder, specific phobias, acute stress disorder), depression, drug dependence, spasm, tremor, pain, Parkinson's disease, attention deficit hyperactivity disorder, bipolar disorder, eating disorder, or sleep disorders, which is based on the glycine uptake-inhibiting action.

A mild chemoselective and rapid regeneration of alcohols from O-allyl ethers by LiCl/NaBH4

An efficient chemoselective cleavage of O-allyl protected is developed employing LiCl/NaBH4.

A Mild and Rapid Regeneration of Alcohols from Allyl Ethers by ZrCl4/NaBH4

A new extremely facile, spontaneous and efficient cleavage of allyl protection is developed employing ZrCl4/NaBH4.

A STEREOSELECTIVE SYNTHESIS OF N-BOC-α-AMINO ALCOHOLS AND α-AMINO ACIDS

A sterteoselective synthesis of N-Boc-α-amino alcohols and α-amino acids via the addition of Grignard reagents to the chiral electrophilic glycine equivalent α-bromo-N-Boc-glycine(-)phenylmenthylester is described.