1421227-52-2 Usage
Uses
1. Used in Pharmaceutical Industry:
N-(6-4-[(4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenylcarbamoyl)amino]phenoxypyrimidin-4-yl)cyclopropanecarboxamide is used as a potential therapeutic agent for various medical conditions due to its unique chemical structure and biological activities.
2. Used in Treatment of Diabetes Type I:
N-(6-4-[(4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenylcarbamoyl)amino]phenoxypyrimidin-4-yl)cyclopropanecarboxamide is used as a β-cell proliferation inducer via the IκB kinase pathway and modulation of the Erb3 binding-protein. This makes it a potential treatment and cure for diabetes type I, as it may help in the regeneration and maintenance of insulin-producing cells in the pancreas.
3. Used in Drug Delivery Systems:
Similar to gallotannin, N-(6-4-[(4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenylcarbamoyl)amino]phenoxypyrimidin-4-yl)cyclopropanecarboxamide may also benefit from novel drug delivery systems to enhance its applications and efficacy against specific medical conditions. Various organic and metallic nanoparticles could be employed as carriers for N-(6-{4-[({4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}carbamoyl)amino]phenoxy}pyrimidin-4-yl)cyclopropanecarboxamide, aiming to improve its delivery, bioavailability, and therapeutic outcomes.
Biological Activity
ws 3 is an agonist of trpm8 receptor with ec50 value of 3.7 μm [1].transient receptor potential cation channel subfamily m member 8 (trpm8) is a ca2+- and na+-permeable ion channel and is activated by cooling agents and cold temperatures. trpm8 belongs to trp family and is expressed in sensory neurons.ws 3 is an agonist of trpm8 receptor and a cooling agent. in hek293 cells expressed recombinant mouse trpm8, ws 3 (30 μm) increased [ca2+]i. ws 3 exhibited potency with ec50 value of 3.7 μm and induced 86% efficacy of the maximal response to icilin, the most potent agonist [1]. in hek cells stably expressing either htrpm8 or htrpa1, ws 3 activated htrpm8 and htrpa1 with ec50 values of 2.2 and 120.6 μm, respectively. ws 3 was efficacious in eliciting cooling sensation [2].
references
[1]. behrendt hj, germann t, gillen c, et al. characterization of the mouse cold-menthol receptor trpm8 and vanilloid receptor type-1 vr1 using a fluorometric imaging plate reader (flipr) assay. br j pharmacol, 2004, 141(4): 737-745.[2]. klein ah, iodi carstens m, mccluskey ts, et al. novel menthol-derived cooling compounds activate primary and second-order trigeminal sensory neurons and modulate lingual thermosensitivity. chem senses, 2011, 36(7): 649-658.
Check Digit Verification of cas no
The CAS Registry Mumber 1421227-52-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,2,1,2,2 and 7 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1421227-52:
(9*1)+(8*4)+(7*2)+(6*1)+(5*2)+(4*2)+(3*7)+(2*5)+(1*2)=112
112 % 10 = 2
So 1421227-52-2 is a valid CAS Registry Number.
1421227-52-2Relevant academic research and scientific papers
Small-molecule inducer of β cell proliferation identified by high-throughput screening
Shen, Weijun,Tremblay, Matthew S.,Deshmukh, Vishal A.,Wang, Weidong,Filippi, Christophe M.,Harb, George,Zhang, You-Qing,Kamireddy, Anwesh,Baaten, Janine E,Jin, Qihui,Wu, Tom,Swoboda, Jonathan G.,Cho, Charles Y.,Li, Jing,Laffitte, Bryan A.,McNamara, Peter,Glynne, Richard,Wu, Xu,Herman, Ann E.,Schultz, Peter G.
, p. 1669 - 1672 (2013/04/23)
The identification of factors that promote β cell proliferation could ultimately move type 1 diabetes treatment away from insulin injection therapy and toward a cure. We have performed high-throughput, cell-based screens using rodent β cell lines to ident
