1421312-33-5

Basic information

• Product Name: methyl 4-hydroxy-1-chloro-7-phenoxyisoquinoline-3-carboxylate
• Synonyms: methyl 4-hydroxy-1-chloro-7-phenoxyisoquinoline-3-carboxylate
• CAS NO: 1421312-33-5
• Molecular Weight: 329.74
• Mol File: 1421312-33-5.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: methyl 4-hydroxy-1-chloro-7-phenoxyisoquinoline-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 4-hydroxy-1-chloro-7-phenoxyisoquinoline-3-carboxylate(1421312-33-5)
• EPA Substance Registry System: methyl 4-hydroxy-1-chloro-7-phenoxyisoquinoline-3-carboxylate(1421312-33-5)

Safety Data

• Hazardous Substances Data: 1421312-33-5(Hazardous Substances Data)

Usage

General Description

Methyl 4-hydroxy-1-chloro-7-phenoxyisoquinoline-3-carboxylate is a chemical compound with a complex structure. It contains a methyl group, a hydroxy group, a chlorine atom, a phenoxy group, and a carboxylate group attached to an isoquinoline ring. The compound may have potential uses in various fields including pharmaceuticals, agrochemicals, or materials science. It is important to handle and use this chemical with proper precaution due to its potential reactivity and toxicity. Its precise properties and potential applications would need to be further studied and understood.

Upstream product

• 1455091-10-7 4-hydroxy-7-phenoxyisoquinoline-3-carboxylic acid methyl ester 
• 1421312-32-4 C₁₇H₁₃NO₅ 
• 21345-01-7 4-phenoxyphthalic anhydride 
• 37951-15-8 4-phenoxyphthalic acid 
• 38791-62-7 4-phenoxyphthalonitrile 
• 31643-49-9 4-Nitrophthalonitrile 

Downstream Products

• 1421312-34-6 4-hydroxy-1-methyl-7-phenoxyisoquinolinyl-3-carboxylic acid methyl ester 
• 808118-40-3 [(4-hydroxy-1-methyl-7-phenoxy-isoquinoline-3-carbonyl)-amino]-acetic acid 
• 1421312-35-7 4-hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid 
• 1421312-36-8 [(4-hydroxy-1-methyl-7-phenoxy-isoquinoline-3-carbonyl)amino]acetic acid methyl ester 

Relevant articles and documents

Preparation method of roxadustat intermediate

The invention discloses a preparation method of a roxadustat intermediate. The method comprises the following steps: anhydride ring opening, esterification, ring closing, aromatization, deprotection, chlorination and methylation to obtain the roxadustat intermediate. According to the invention, the preparation method provided by the invention makes full use of the atom economy theory, is easy to operate, low in cost and low in pollution, and is suitable for large-scale industrial production; and only one-time refining is carried out, the chromatographic purity can reach 99.5% or above, and the total yield of the six-step reaction is 30% or above.

Isoquinolone compound and application thereof

The invention relates to an isoquinolone compound and application thereof. The invention in particular relates to an isoquinolone compound used as a HIF prolyl hydroxylase inhibitor (HIF-PHI) and a pharmaceutical composition thereof. Moreover, the present invention provides the application of the isoquinolinone compound or the pharmaceutical composition thereof in the preparation of a medicament for preventing or treating HIF-associated or HIF-mediated diseases as anemia or ischemia, local ischemia or hypoxia.

CRYSTAL TYPES OF COMPOUNDS INHIBITING ACTIVITY OF PROLYL HYDROXYLASE AND USE THEREOF

The invention relates to crystal types of compound shown as structural formula I, methods of preparing the compound, intermediate, pharmaceutical composition, and use of treating disease or pharmaceutical preparations for treating disease.