1421316-70-2

Upstream product

• 141645-16-1 2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran 
• 1278585-68-4 (5-amino-2-butyl-1-benzofuran-3-yl)(4-hydroxyphenyl)methanone 
• 1278585-70-8 N-[2-butyl-3-(4-hydroxybenzoyl)-1-benzofuran-5-yl]methanesulfonamide 
• 98-88-4 benzoyl chloride 

Downstream Products

• 141626-36-0 dronedarone 
• 1421316-69-9 N,N-dibutyl-3-[4-((2-butyl-5-[(methylsulfonyl)amino]-1-benzofuran-3-yl)carbonyl)-phenoxy]propanamide 

Relevant academic research and scientific papers

PROCESS FOR PREPARATION OF DRONEDARONE USING AMIDE INTERMEDIARY COMPOUND

The invention relates to a novel process for preparation of dronedarone of formula (I) and pharmaceutically acceptable salts thereof characterized in that the compound of formula (II) is reduced, and the obtained product is isolated and, if desired, converted into a pharmaceutically acceptable salt thereof. The invention also relates to some novel intermediary compounds and the preparation thereof.