1421335-87-6

Upstream product

• 86227-42-1 methyl 4-benzyloxy-2-methylbutanoate 
• 31600-42-7 methyl 4-(benzyloxy)butanoate 
• 6148-64-7 ethyl potassium malonate 
• 823180-17-2 methyl 4-(benzyloxy)-2,2-dimethylbutanoate 
• 10385-30-5 4-(benzyloxy)butanoic acid 

Downstream Products

• 1427193-63-2 C₂₄H₂₈N₂O₃ 
• 1427193-65-4 ethyl 5-(4-hydroxy-2-methylbutan-2-yl)-1-phenyl-1H-pyrazole-4-carboxylate 
• 1427193-67-6 ethyl 1-phenyl-5-(2-methyl-4-oxobutan-2-yl)-1H-pyrazole-4-carboxylate 

Relevant academic research and scientific papers

Discovery of novel 7-membered cyclic amide derivatives that inhibit 11beta-hydroxysteroid dehydrogenase type 1

A series of novel 5-trans-hydroxyadamantan-2-yl-5,6,7,8- tetrahydropyrazolo[4,3-c]azepin-4(1H)-ones that inhibit 11beta-hydroxysteroid dehydrogenase type 1 are described. We discovered these 7-membered cyclic amide derivatives by introducing a distinctive linker through pharmacophore analysis of known ligands included in X-ray co-crystal structures. Further optimization using docking studies led to highly potent inhibitors 15b and 27, which furthermore showed the potent efficacy in in vivo studies.