823180-17-2

Upstream product

• 54555-84-9 benzyl iodoethyl ether 
• 547-63-7 Methyl isobutyrate 
• 100-39-0 benzyl bromide 
• 86227-42-1 methyl 4-benzyloxy-2-methylbutanoate 
• 74-88-4 methyl iodide 
• 31600-42-7 methyl 4-(benzyloxy)butanoate 
• 10385-30-5 4-(benzyloxy)butanoic acid 
• 68972-96-3 (Z)-1,4-dibenzyloxy-2-butene 
• 622-08-2 2-Benzyloxyethanol 

Downstream Products

• 1421335-87-6 ethyl 6-benzyloxy-4,4-dimethyl-3-oxohexanoate 
• 1427193-65-4 ethyl 5-(4-hydroxy-2-methylbutan-2-yl)-1-phenyl-1H-pyrazole-4-carboxylate 
• 1427193-63-2 C₂₄H₂₈N₂O₃ 
• 1427193-67-6 ethyl 1-phenyl-5-(2-methyl-4-oxobutan-2-yl)-1H-pyrazole-4-carboxylate 
• 1421335-95-6 C₂₃H₃₆N₂O₃Si 
• 1421335-96-7 C₁₇H₂₂N₂O₃ 
• 1421335-97-8 C₁₇H₂₀N₂O₃ 
• 1421335-94-5 C₁₉H₃₄O₂Si 
• 370555-60-5 4-(benzyloxy)-2,2-dimethylbutanal 
• 823180-03-6 (((5,5-diiodo-3,3-dimethylpent-4-enyl)oxy)methyl)benzene 
• 370555-59-2 4-(benzyloxy)-2,2-dimethylbutan-1-ol 

Relevant academic research and scientific papers

Discovery of novel 7-membered cyclic amide derivatives that inhibit 11beta-hydroxysteroid dehydrogenase type 1

A series of novel 5-trans-hydroxyadamantan-2-yl-5,6,7,8- tetrahydropyrazolo[4,3-c]azepin-4(1H)-ones that inhibit 11beta-hydroxysteroid dehydrogenase type 1 are described. We discovered these 7-membered cyclic amide derivatives by introducing a distinctive linker through pharmacophore analysis of known ligands included in X-ray co-crystal structures. Further optimization using docking studies led to highly potent inhibitors 15b and 27, which furthermore showed the potent efficacy in in vivo studies.

Highly efficient two-step synthesis of C-sp3-centered geminal diiodides

(Chemical Equation Presented) Trisubstituted gem-diiodoalkenes of functionalized chains are efficiently reduced to the corresponding terminal geminal diiodides in high yields upon treatment with the diazene precursor, diethyl 4-(hydrazinosulfonyl)-benzyl phosphonate.