1421365-49-2

Basic information

• Product Name: C₂₁H₁₆ClN₃O₃
• CAS NO: 1421365-49-2
• Molecular Weight: 393.829
• Mol File: 1421365-49-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₁H₁₆ClN₃O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₁H₁₆ClN₃O₃(1421365-49-2)
• EPA Substance Registry System: C₂₁H₁₆ClN₃O₃(1421365-49-2)

Safety Data

• Hazardous Substances Data: 1421365-49-2(Hazardous Substances Data)

Upstream product

• 110333-07-8 5-(chloromethyl)quinoline 
• 1421365-17-4 C₁₁H₉ClN₂O₃ 

Relevant articles and documents

SAR analysis of novel non-peptidic NPBWR1 (GPR7) antagonists

In this Letter we report on the advances in our NPBWR1 antagonist program aimed at optimizing the 5-chloro-2-(3,5-dimethylphenyl)-4-(4-methoxyphenoxy) pyridazin-3(2H)-one lead molecule previously obtained from a high-throughput screening (HTS)-derived hit. Synthesis and structure-activity relationships (SAR) studies around the 3,5-dimethylphenyl and 4-methoxyphenyl regions resulted in the identification of a novel series of non-peptidic submicromolar NPBWR1 antagonists based on a 5-chloro-4-(4-alkoxyphenoxy)-2-(benzyl)pyridazin-3(2H)- one chemotype. Amongst them, 5-chloro-2-(9H-fluoren-9-yl)-4-(4-methoxyphenoxy) pyridazin-3(2H)-one 9h (CYM50769) inhibited NPW activation of NPBWR1 with a submicromolar IC50, and displayed high selectivity against a broad array of off-targets with pharmaceutical relevance. Our medicinal chemistry study provides innovative non-peptidic selective NPBWR1 antagonists that may enable to clarify the biological role and therapeutic utility of the target receptor in the regulation of feeding behavior, pain, stress, and neuroendocrine function.