110333-07-8

Basic information

• Product Name: 5-Chloromethylquinoline
• Synonyms: 5-Chloromethylquinoline;Quinoline, 5-(chloromethyl)-
• CAS NO: 110333-07-8
• Molecular Formula: C₁₀H₈ClN
• Molecular Weight: 177.63022
• Mol File: 110333-07-8.mol
• Article Data: 4

Chemical Properties

• Melting Point: 90-90.5 °C
• Boiling Point: 310.6±17.0 °C(Predicted)
• Appearance: /
• Density: 1.229±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 4.55±0.12(Predicted)
• CAS DataBase Reference: 5-Chloromethylquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Chloromethylquinoline(110333-07-8)
• EPA Substance Registry System: 5-Chloromethylquinoline(110333-07-8)

Safety Data

• Hazardous Substances Data: 110333-07-8(Hazardous Substances Data)

Usage

General Description

5-Chloromethylquinoline is a chemical compound with the molecular formula C10H8ClN. It is a quinoline derivative that contains a chlorine atom and a methyl group attached to the quinoline ring. 5-Chloromethylquinoline is commonly used as a building block in organic synthesis and medicinal chemistry. It has been found to exhibit antimicrobial, anti-inflammatory, and anticancer properties, making it a potential candidate for drug development. Additionally, 5-Chloromethylquinoline has been used in the production of various pharmaceuticals and agrochemicals due to its versatile reactivity and bioactivity. It is important to handle this chemical with caution as it may pose potential health hazards if not used properly.

Upstream product

• 22934-41-4 quinoline-5-carbaldehyde 
• 16178-42-0 quinolin-5-ylmethanol 

Downstream Products

• 1146365-37-8 5,5'-(4-(trifluoromethyl)benzylazanediyl)bis-(methylene)diquinoline 
• 555155-04-9 2-(quinolin-5-yl)acetonitrile 
• 1421365-49-2 C₂₁H₁₆ClN₃O₃ 

Relevant articles and documents

PYRIDAZINONES AND METHODS OF USE THEREOF

Disclosed are compounds according to Formula (A), and related tautomers and pharmaceutical compositions. Also disclosed are therapeutic methods, e.g., of treating kidney diseases, using the compounds of Formula (A).

Discovery of pyridyl-based inhibitors of Plasmodium falciparum N-myristoyltransferase

N-Myristoyltransferase (NMT) represents an attractive drug target in parasitic infections such as malaria due to its genetic essentiality and amenability to inhibition by drug-like small molecules. Scaffold simplification from previously reported inhibitors containing bicyclic cores identified phenyl derivative 3, providing a versatile platform to study the effects of substitution on the scaffold, which yielded pyridyl 19. This molecule exhibited improved enzyme and cellular potency, and reduced lipophilicity compared to inhibitor 3. Further structure-based inhibitor design led to the discovery of 30, the most potent inhibitor in this series, which showed single-digit nM enzyme affinity and sub-μM anti-plasmodial activity.