1421367-67-0Relevant articles and documents
Design and Development of a Chemical Probe for Pseudokinase Ca2+/calmodulin-Dependent Ser/Thr Kinase
Aydogan, Yagmur,Berger, Benedict-Tilman,Chaikuad, Apirat,Drewry, David H.,Knapp, Stefan,Müller, Susanne,Mandel, Sebastian,Mauer, Sandy,Pohl, Christian,Russ, Nadine,Schr?der, Martin
, p. 14358 - 14376 (2021/10/12)
CASK (Ca2+/calmodulin-dependent Ser/Thr kinase) is a member of the MAGUK (membrane-associated guanylate kinase) family that functions as neurexin kinases with roles implicated in neuronal synapses and trafficking. The lack of a canonical DFG motif, which
Optimization of highly selective 2,4-diaminopyrimidine-5-carboxamide inhibitors of Sky kinase
Powell, Noel A.,Hoffman, Jennifer K.,Ciske, Fred L.,Kohrt, Jeffrey T.,Baxi, Sangita M.,Peng, Yun-Wen,Zhong, Min,Catana, Cornel,Ohren, Jeff,Perrin, Lisa A.,Edmunds, Jeremy J.
, p. 1051 - 1055 (2013/03/13)
Optimization of the ADME properties of a series of 2,4-diaminopyrimidine-5- carboxamide inhibitors of Sky kinase resulted in the identification of highly selective compounds with properties suitable for use as in vitro and in vivo tools to probe the effects of Sky inhibition.