74840-34-9 Usage
Description
4-chloro-2-(methylthio)pyrimidine-5-carboxylic acid is a pyrimidine derivative with a molecular formula C7H7ClN2O2S. It features a chloro substituent at the 4 position, a methylthio group at the 2 position, and a carboxylic acid group at the 5 position. 4-chloro-2-(methylthio)pyrimidine-5-carboxylic acid is known for its diverse biological activities and is widely used as an intermediate in the synthesis of pharmaceuticals and agrochemicals.
Uses
Used in Pharmaceutical Industry:
4-chloro-2-(methylthio)pyrimidine-5-carboxylic acid is used as an intermediate in the synthesis of various pharmaceuticals for its potential anti-cancer, anti-inflammatory, and antimicrobial properties. Its unique structural characteristics and reactivity make it a valuable compound in the development of new drugs.
Used in Agrochemical Industry:
In the agrochemical industry, 4-chloro-2-(methylthio)pyrimidine-5-carboxylic acid is utilized as an intermediate in the production of agrochemicals, contributing to the development of effective pesticides and other agricultural chemicals.
Used in Organic Chemistry:
4-chloro-2-(methylthio)pyrimidine-5-carboxylic acid is employed as a key building block in organic chemistry due to its reactivity and structural features. It serves as a versatile starting material for the synthesis of various organic compounds.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 4-chloro-2-(methylthio)pyrimidine-5-carboxylic acid is used for its potential applications in drug discovery and development. Its unique properties and reactivity make it a promising candidate for the design and synthesis of novel therapeutic agents.
Check Digit Verification of cas no
The CAS Registry Mumber 74840-34-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,4,8,4 and 0 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 74840-34:
(7*7)+(6*4)+(5*8)+(4*4)+(3*0)+(2*3)+(1*4)=139
139 % 10 = 9
So 74840-34-9 is a valid CAS Registry Number.
InChI:InChI=1/C6H5ClN2O2S/c1-12-6-8-2-3(5(10)11)4(7)9-6/h2H,1H3,(H,10,11)
74840-34-9Relevant articles and documents
CYCLIN-DEPENDENT KINASE INHIBITORS
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Page/Page column 204, (2020/07/15)
Described herein are compounds and their pharmaceutically acceptable salts, pharmaceutical compositions thereof, methods of treatment, and medical uses. The compounds described herein are modulators of cyclin-dependent kinases, and are useful in the treatment or alleviation of protein kinase associated disorders, including cancer, infectious diseases, autoimmune diseases, or cardiovascular diseases.
C5-substituted pyrido[2,3-d]pyrimidin-7-ones as highly specific kinase inhibitors targeting the clinical resistance-related EGFRT790M mutant
Xu, Tianfeng,Peng, Ting,Ren, Xiaomei,Zhang, Lianwen,Yu, Lei,Luo, Jinfeng,Zhang, Zhang,Tu, Zhengchao,Tong, Linjiang,Huang, Zhaoru,Lu, Xiaoyun,Geng, Meiyu,Xie, Hua,Ding, Jian,Ding, Ke
supporting information, p. 1693 - 1697 (2015/09/21)
The development of specific kinase inhibitors has been a long-standing challenge in chemical biology and drug discovery. We have successfully discovered a series of C5-substituted pyrido[2,3-d]pyrimidin-7-ones as highly specific inhibitors against the clinical resistance-related EGFRT790M mutant. One of the most promising compounds, 9f, tightly binds to the EGFRT790M mutant and strongly inhibits its enzymatic function with an IC50 value of 0.80 nM, and displays an extraordinary target specificity with S(35) and S(10) selectivity scores of 0.005 and 0.000, respectively, in a kinase selectivity profiling study against 456 different kinases at 100 nM. The compound also selectively suppresses the proliferation of EGFRT790M mutated H1975 NSCLC cells with an IC50 value of 2.80 nM, but is significantly less toxic to cells with wild-type EGFR. Compound 9f may serve as a promising lead compound for drug discovery overcoming the acquired resistance of NSCLC patients without adverse toxicities.