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1421373-62-7

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1421373-62-7 Usage

General Description

Mutant EGFR inhibitors are a class of chemicals designed to specifically target and inhibit the activity of mutant forms of the epidermal growth factor receptor (EGFR) protein. These mutant forms of EGFR are often found in cancer cells and are associated with excessive cell growth and proliferation. By inhibiting the activity of mutant EGFR, these inhibitors can help to block the signals that drive the growth of cancer cells, ultimately leading to a reduction in tumor growth and spread. Mutant EGFR inhibitors have shown promising results in preclinical and clinical studies, and are being actively pursued as a potential treatment for various types of cancer, particularly those driven by mutant forms of EGFR.

Check Digit Verification of cas no

The CAS Registry Mumber 1421373-62-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,2,1,3,7 and 3 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1421373-62:
(9*1)+(8*4)+(7*2)+(6*1)+(5*3)+(4*7)+(3*3)+(2*6)+(1*2)=127
127 % 10 = 7
So 1421373-62-7 is a valid CAS Registry Number.

1421373-62-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name N-(5-((5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide

1.2 Other means of identification

Product number -
Other names N-(5-((5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1421373-62-7 SDS

1421373-62-7Downstream Products

1421373-62-7Relevant articles and documents

HETEROARYL COMPOUNDS FOR KINASE INHIBITION

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Paragraph 528, (2016/04/26)

Compounds and pharmaceutical compositions that modulate kinase activity, including mutant EGFR and mutant HER2 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including mutant EGFRand mutant HER2 activity, are described herein.

2 - (2, 4, 5 - SUBSTITUTED -ANILINO) PYRIMIDINE DERIVATIVES AS EGFR MODULATORS USEFUL FOR TREATING CANCER

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, (2013/03/26)

The present invention relates to certain 2-(2,4,5-substituted-anilino) pyrimidine compounds and pharmaceutically acceptable salts thereof which may be useful in the treatment or prevention of a disease or medical condition mediated through certain mutated forms of epidermal growth factor receptor (for example the L858R activating mutant, the Exonl9 deletion activating mutant and the T790M resistance mutant). Such compounds and salts thereof may be useful in the treatment or prevention of a number of different cancers. The invention also relates to pharmaceutical compositions comprising said compounds and salts thereof, especially useful polymorphic forms of these compounds and salts, intermediates useful in the manufacture of said compounds and to methods of treatment of diseases mediated by various different forms of EGFR using said compounds and salts thereof.

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