142148-11-6

Usage

Derivation

A derivative of cyclopropane and benzoic acid

Physical state

Colorless liquid

Aroma

Pleasant

Solubility

Insoluble in water, soluble in organic solvents

Uses

Building block for the synthesis of various organic compounds, used in the manufacture of fragrances, pharmaceuticals, and other industrial products

Reactivity

Potential use as a reagent in organic chemistry for the formation of carbon-carbon bonds and other chemical transformations

Toxicity

Relatively low toxicity, but proper safety precautions should be taken when handling and using this chemical

Upstream product

• 441785-04-2 (1-(((tert-butyldiphenylsilyl)oxy)methyl)cyclopropyl)methanol 
• 39590-81-3 [1-(hydroxymethyl)cyclopropyl]methanol 
• 98-88-4 benzoyl chloride 
• 90238-20-3 N,N-diethyl-α,α-difluorobenzylamine 

Relevant academic research and scientific papers

SUBSTITUTED PYRAZOLOAZEPIN-4-ONES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS

The present invention relates to novel substituted pyrazoloazepin-4-ones with phosphodiesterase inhibitory activity, as well as to their use as therapeutic agents in the treatment of inflammatory diseases and conditions.

PYRIDYL OR PYRAZINYL COMPOUNDS CARRYING A METHYL-BOUND ALPHA-AMINO ACID AMIDE GROUP

The present invention relates to pyridyl or pyrazinyl compounds carrying a methyl- bound N-amide moiety derived from an α-amino acid of formula I where the variables are as defined in the claims and the description. The invention further relates to a pharmaceutical composition containing such compounds, to their use as modulators, especially agonists or partial agonists, of the 5-HT2C receptor, and to their use for preparing a medicament for the prevention or treatment of conditions and disorders which respond to the modulation of the 5-HT2C receptor.

Selective mono-acylation of 1,2- and 1,3-diols using (α,α- difluoroalkyl)amines

In the reaction of N,N-diethyl-α,α-difluorobenzylamine (DFBA) with 1,2- or 1,3-diols, selective mono-benzoylation occurs to afford mono-esters of the diols in good yield. The reaction is completed under mild conditions in a short reaction time. Further, prim-, sec-, and tert-diols and catechol can be converted to the corresponding mono-benzoates. DFBA is used for the protection of the hydroxy group in sugars. The selective mono-nicotinylation, formylation and pivaloylation of diols are also performed by using the corresponding difluoroalkylamines.