1421503-41-4

Basic information

• Product Name: 6-[2-ethyl-5-fluoro-4-(2-trimethylsilanyl-ethoxymethoxy)phenyl]-1-(tetrahydro-pyran-2-yl)-1H-indazole-3-carbonitrile
• Synonyms: 6-[2-ethyl-5-fluoro-4-(2-trimethylsilanyl-ethoxymethoxy)phenyl]-1-(tetrahydro-pyran-2-yl)-1H-indazole-3-carbonitrile
• CAS NO: 1421503-41-4
• Molecular Weight: 495.669
• Mol File: 1421503-41-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 6-[2-ethyl-5-fluoro-4-(2-trimethylsilanyl-ethoxymethoxy)phenyl]-1-(tetrahydro-pyran-2-yl)-1H-indazole-3-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 6-[2-ethyl-5-fluoro-4-(2-trimethylsilanyl-ethoxymethoxy)phenyl]-1-(tetrahydro-pyran-2-yl)-1H-indazole-3-carbonitrile(1421503-41-4)
• EPA Substance Registry System: 6-[2-ethyl-5-fluoro-4-(2-trimethylsilanyl-ethoxymethoxy)phenyl]-1-(tetrahydro-pyran-2-yl)-1H-indazole-3-carbonitrile(1421503-41-4)

Safety Data

• Hazardous Substances Data: 1421503-41-4(Hazardous Substances Data)

Upstream product

• 1421503-36-7 6-bromo-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole-3-carbaldehyde 
• 110-87-2 3,4-dihydro-2H-pyran 
• 1421503-37-8 6-bromo-1-(tetrahydro-pyran-2-yl)-1H-indazole-3-carbonitrile 
• 1421503-40-3 (2-{[2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5-ethyl-phenoxy]methoxy}ethyl)(trimethyl)silane 
• 1421503-38-9 4-bromo-5-ethyl-2-fluoro-phenol 
• 891843-05-3 5-ethyl-2-fluoro-phenol 
• 885271-72-7 6-bromo-1H-indazol-3-yl-carbaldehyde 

Downstream Products

• 1421503-43-6 N-(1-benzyl-4,4-diethoxy-piperidin-3-yl)-6-[2-ethyl-5-fluoro-4-(2-trimethylsilanyl-ethoxymethoxy)phenyl]-1-(tetrahydro-pyran-2-yl)-1H-indazole-3-carboxamidine 
• 1421503-44-7 4,4-diethoxy-3-{[6-[2-ethyl-5-fluoro-4-(2-trimethylsilanyl-ethoxymethoxy)phenyl]-1-(tetrahydro-pyran-2-yl)-1H-indazole-3-carboximidoyl]amino}piperidine-1-carboxylic acid tert-butyl ester 
• 1421502-61-5 N-(1-benzyl-4,4-diethoxy-piperidin-3-yl)-6-(2-ethyl-5-fluoro-4-hydroxy-phenyl)-1-(tetrahydro-pyran-2-yl)-1H-indazole-3-carboxamidine 
• 1421503-42-5 6-[2-ethyl-5-fluoro-4-(2-trimethylsilanyl-ethoxymethoxy)phenyl]-1-(tetrahydro-pyran-2-yl)-1H-indazole-3-carboximidic acid methyl ester 

Relevant articles and documents

Design and synthesis of a Pan-Janus kinase inhibitor clinical candidate (PF-06263276) suitable for inhaled and topical delivery for the treatment of inflammatory diseases of the lungs and skin

By use of a structure-based computational method for identification of structurally novel Janus kinase (JAK) inhibitors predicted to bind beyond the ATP binding site, a potent series of indazoles was identified as selective pan-JAK inhibitors with a type 1.5 binding mode. Optimization of the series for potency and increased duration of action commensurate with inhaled or topical delivery resulted in potent pan-JAK inhibitor 2 (PF-06263276), which was advanced into clinical studies.