885271-72-7

Usage

Uses

Used in Pharmaceutical Industry:
6-BROMO-1H-INDAZOLE-3-CARBALDEHYDE is used as a key intermediate in the synthesis of various pharmaceutical compounds for its ability to be incorporated into the molecular structures of new drugs. Its heterocyclic structure allows for the development of drugs targeting a wide range of diseases, making it a valuable asset in the pharmaceutical industry.
Used in Agrochemical Industry:
6-BROMO-1H-INDAZOLE-3-CARBALDEHYDE is used as an intermediate in the production of agrochemical compounds, contributing to the development of new pesticides, herbicides, and other agricultural chemicals. Its unique chemical properties enable the creation of effective and targeted agrochemicals to improve crop protection and yield.
Used in Organic Synthesis:
6-BROMO-1H-INDAZOLE-3-CARBALDEHYDE is used as a building block in organic synthesis for the creation of diverse chemical compounds. Its versatility and reactivity make it a valuable component in the synthesis of various organic compounds, including those with potential applications in materials science, chemical research, and other industries.
Used in Antimicrobial and Antiviral Research:
6-BROMO-1H-INDAZOLE-3-CARBALDEHYDE has been studied for its potential antimicrobial and antiviral properties, making it a candidate for the development of new treatments and therapies against infectious diseases. Its unique chemical structure allows for the exploration of its efficacy against various pathogens, contributing to the advancement of medical research in this field.

InChI:InChI=1/C8H5BrN2O/c9-5-1-2-6-7(3-5)10-11-8(6)4-12/h1-4H,(H,10,11)

Upstream product

• 52415-29-9 6-bromo-1H-indole 
• 60956-26-5 4-bromo-2-nitrotoluene 
• 68-12-2 N,N-dimethyl-formamide 
• 67-64-1 acetone 

Downstream Products

• 1421503-37-8 6-bromo-1-(tetrahydro-pyran-2-yl)-1H-indazole-3-carbonitrile 
• 1421503-41-4 6-[2-ethyl-5-fluoro-4-(2-trimethylsilanyl-ethoxymethoxy)phenyl]-1-(tetrahydro-pyran-2-yl)-1H-indazole-3-carbonitrile 
• 1421503-42-5 6-[2-ethyl-5-fluoro-4-(2-trimethylsilanyl-ethoxymethoxy)phenyl]-1-(tetrahydro-pyran-2-yl)-1H-indazole-3-carboximidic acid methyl ester 

Relevant academic research and scientific papers

JAK inhibitor compound and application thereof

The invention relates to a JAK inhibitor compound and application thereof. Specifically, the invention discloses a compound shown as a formula (G), or an isotope labeled compound, or an optical isomer, a geometrical isomer, a tautomer or an isomer mixture of the compound, or a pharmaceutically acceptable salt of the compound, or a prodrug of the compound, or a metabolite of the compound. The invention also relates to the medical application of the compound.

2-AZABICYCLO HEXANE JAK INHIBITOR COMPOUND

The invention provides a compound of formula 1 or a pharmaceutically-acceptable salt thereof, that is useful as a JAK inhibitor. The invention also provides pharmaceutical compositions comprising the compound, methods of using the compound to treat diseas

3-formyl-1H-substituted indazole and preparation method thereof

The embodiment of the invention discloses 3-formyl-1H-substituted indazole and a preparation method thereof. The method comprises the step of taking 2-nitro-substituted toluene as a raw material to prepare a compound in a formula (VI). The method takes the 2-nitro-substituted toluene as the raw material to prepare the 3-formyl-1H-substituted indazole. The raw material used by the preparation method is cheap and easy to get; a product with relatively high purity can be obtained without column chromatography separation and purification; the method can be well applied to practical production andapplication. Further, reaction conditions required by a whole preparation process are mild; the use of reagents with strong reducibility or strong oxidability is not involved; the method is suitable for industrial production.

An optimized procedure for direct access to 1: H -indazole-3-carboxaldehyde derivatives by nitrosation of indoles

Indazole derivatives are currently drawing more and more attention in medicinal chemistry as kinase inhibitors. 1H-indazole-3-carboxaldehydes are key intermediates to access to a variety of polyfunctionalized 3-substituted indazoles. We report here a general access to this motif, based on the nitrosation of indoles in a slightly acidic environment. These very mild conditions allow the conversion of both electron-rich and electron-deficient indoles into 1H-indazole-3-carboxaldehydes.

JAK KINASE INHIBITOR COMPOUNDS FOR TREATMENT OF RESPIRATORY DISEASE

The invention provides compounds of formula (I): wherein X is (I) and the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are useful as JAK kinase inhibitors. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat respiratory diseases, and processes and intermediates useful for preparing such compounds.

HEPARAN SULFATE BIOSYNTHESIS INHIBITORS FOR THE TREATMENT OF DISEASES

Described herein are compounds of Formula I, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or conditions in need of inhibition of heparan sulfate biosynthesis.

An indazole compound derivatives and its preparation method

The invention relates to an indazole compound derivative and a preparation method thereof. The indazole compound derivative is 6-bromine-3-acetyl indazole. The preparation method comprises the following steps: (1) a compound 1, namely 6-bromine-indole, reacts with sodium nitrite and hydrochloric acid to generate a compound 2; (2) the compound 2 reacts with di-tert-butyl dicarbonate ester to generate a compound 3 (Boc-protected indazole carboxaldehyde); (3) the compound 3 is reduced with sodium boro-hydride to generate a compound 4; (4) the indazole hydroxy of the compound 4 is oxidized into indazole acetyl by manganese dioxide to obtain the end product, namely the compound 5. The end product has a wide application prospect in the aspects such as curing of inflammation related diseases.

AROMATIC HETEROCYCLIC COMPOUNDS AND THEIR APPLICATION IN PHARMACEUTICALS

Provided herein are novel aromatic heterocyclic compounds or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a hydrate, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof, and their uses for treating Alzheimer's disease. Also provided herein are pharmaceutical compositions containing such compounds, and methods for using such compounds or pharmaceutical compositions thereof to treat Alzheimer's disease.

COMPOSITION FOR PREVENTION OR TREATMENT OF HEART FAILURE

Provided are a composition for preventing or treating heart failure and a method for screening an agent for treating heart failure. The present disclosure demonstrates for the first time that administration of PKC zeta inhibitor provides inotropic effect

2-(6-Phenyl-1H-indazol-3-yl)-1H-benzo[d]imidazoles: Design and synthesis of a potent and isoform selective PKC-ζ inhibitor

The inhibition of PKC-ζ has been proposed to be a potential drug target for immune and inflammatory diseases. A series of 2-(6-phenyl-1H indazol-3-yl)-1H-benzo[d]imidazoles with initial high crossover to CDK-2 has been optimized to afford potent and selec