14216-33-2

Upstream product

• 54-21-7 sodium salicylate 
• 541-41-3 chloroformic acid ethyl ester 
• 69-72-7 salicylic acid 
• 121-69-7 N,N-dimethyl-aniline 
• 71-43-2 benzene 
• 64-17-5 ethanol 
• 855178-01-7 C₈H₆O₅ 
• 110-86-1 pyridine 

Downstream Products

• 56076-49-4 2-ethoxycarbonyloxy-benzoyl chloride 
• 552-94-3 2-hydroxy-benzoic acid, 2-carboxyphenyl ester 
• 1310672-89-9 bis(2-(ethoxycarbonyloxy)benzoyl) peroxide 
• 79960-76-2 (2-ethoxycarbonyloxy-benzoyl)-carbonic acid ethyl ester 

Relevant academic research and scientific papers

Synthesis, antiproliferative activity, and molecular docking studies of curcumin analogues bearing pyrazole ring

Several curcumin analogues bearing pyrazole were synthesized and characterized by IR, NMR, and mass spectral data. There were four tested compounds among 11 synthesized compounds, which were evaluated for antiproliferative activity and showed significant activity in both one-dose and five-dose assays. The antiproliferative effects were tested on a panel of 60 cell lines, according to the National Cancer Institute screening protocol. The most active compounds among the series were 3,5-bis(4-hydroxy-3-methylstyryl)-1H-pyrazole-1-carboxamide (3k) which showed mean percent growth inhibition of 116.09 in one-dose assay at 10 μM, and GI50 values were ranging between 0.0912 and 2.36 μM in five-dose assay. The best results were recorded on the leukaemia cell lines with value ranging from 0.0912 to 0.365 μM. All the tested compounds showed broad-spectrum antiproliferative activity over different cancer cell lines. When compared with the standard drug paclitaxel, the compound 3k showed superior activity on nearly 42 cell lines. The molecular docking study was performed to explore the binding interaction of these curcumin analogues with the active site of EGFR tyrosine kinase (EGFR-TK). The hydroxyl group of both phenyl rings was important for the rein-geminated hydrogen bonding by either side chain or backbone with the active site of EGFR-TK. Graphical Abstract: Four curcumin analogues were evaluated for their antiproliferative activity and showed promising results. The molecular docking studies showed that all the compounds (3a-k) were well accommodated in the EGFR tyrosine kinase.[Figure not available: see fulltext.]

NOVEL PEROXIDE DERIVATIVES, THEIR PROCESS OF PREPARATION AND THEIR USE IN HUMAN MEDICINE AND IN COSMETICS FOR THE TREATMENT OR PREVENTION OF ACNE

The present invention relates to the use of the compounds of following general formula (I): It also relates to their process of preparation and to their therapeutic application.

8-Acyloxy-1,3-benzoxazine-2,4-diones as siderophore components for antibiotics

8-Acyloxy-1,3-benzoxazine-2,4-diones as masked catechol derivatives represent a novel type of siderophore components, whose growth promoting activity is low or not existing if tested alone. But after conjugation with β-lactam antibiotics the resulting con