79960-76-2Relevant academic research and scientific papers
Convenient preparation of primary amides via activation of carboxylic acids with ethyl chloroformate and triethylamine under mild conditions
Noguchi, Takuya,Sekine, Masahiro,Yokoo, Yuki,Jung, Seunghee,Imai, Nobuyuki
, p. 580 - 582 (2013/07/05)
Primary amides were easily prepared in 22-99% yields from the corresponding carboxylic acids 1 or 5 with NH4Cl via activation with ClCO 2Et and Et3N. The enantiomers of the corresponding primary amides of Cbz-, Boc-, or Fmoc-α-amino acids can be separated by using a chiral column.
An easy two-step reduction of salicylic acids and alcohols to 2-methylphenols
Mazzini, Francesco,Salvadori, Piero
, p. 2479 - 2481 (2007/10/03)
Salicylic acids and alcohols can be reduced to 2-methylphenols by a simple two steps procedure. Reaction conditions were optimized carrying out a study on the solvent effect and the amount of the reducing agent. The improved procedure resulted particularly useful in the synthesis of deuterated building blocks of biological interest. Georg Thieme Verlag Stuttgart.
THALIDOMIDE ANALOGS
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Page/Page column 40, (2008/06/13)
Thalidomide analogs that modulate tumor necrosis factor alpha (TNF-α) activity and angiogenesis are disclosed. In particularly disclosed embodiments, the thalidomide analogs are isosteric sulfur-containing analogs. Also disclosed are methods of treating a subject with the analogs.
A simple one-pot synthesis of benzoxazine-2,4-diones and benzothiazine-2,4-diones
Zhu, Xiaoxiang,Yu, Qian-sheng,Greig, Nigel H.,Flippen-Anderson, Judith L.,Brossi, Arnold
, p. 115 - 128 (2007/10/03)
A simple and efficient procedure has been developed for a one-pot synthesis of substituted benzoxazine-2,4-diones and benzothiazine-2,4-diones directly from salicylic acid (or thiosalicylic acid) and amines.
