1421640-63-2

Upstream product

• 1421640-68-7 C₁₉H₃₃IO 
• 1421640-67-6 (1R,3aR,5R,7aR)-1-[(R)-1’,5’-dimethyl-5’-[(triethylsilyl)oxy]hexyl]-5,7a-dimethyloctahydroinden-4-one 
• 1421640-75-6 1α-[(tert-butyldimethylsilyl)oxy]-9-methyl-25-[(triethylsilyl)oxy]-previtamin D3 tert-butyldimethylsilyl ether 
• 1421640-74-5 1α,3β-bis[(tert-butyldimethylsilyl)oxy]-9-methyl-25-[(triethylsilyl)oxy]-9,10-secocholesta-5(10),8-dien-6-yne 
• 1421640-73-4 1α,3β-bis[(tert-butyldimethylsilyl)oxy]-9α-methyl-25-[(triethylsilyl)oxy]-9,10-secocholest-5(10)-en-6-yn-8β-ol 
• 1421640-64-3 1α,25-dihydroxy-9-methylprevitamin D₃ 
• 1421640-72-3 1α-[(tert-butyldimethylsilyl)oxy]-25-hydroxy-9-methylprevitamin D₃ tert-butyldimethylsilyl ether 
• 1421640-71-2 C₃₃H₆₆O₂Si₂Sn 
• 144848-24-8 25-[(triethylsilyl)oxy]de-A,B-cholestan-8-one 
• 1421640-70-1 1α,3β-bis[(tert-butyldimethylsilyl)oxy]-25-hydroxy-9-methyl-9,10-secocholesta-5(10),8-dien-6-yne 
• 116506-67-3 TB 

Relevant academic research and scientific papers

Novel 9-Alkyl- and 9-Alkylidene-Substituted 1α,25-Dihydroxyvitamin D3 Analogues: Synthesis and Biological Examinations

Continuing the structure-activity relationship studies in the vitamin D area, we designed and synthesized novel C-9 substituted calcitriol analogues, possessing different nonpolar groups at this position. 9α-Methyl-1α,25-(OH)2D3, bot

Synthesis of 9-alkylated calcitriol and two 1α,25-dihydroxy-9- methylene-10,19-dihydrovitamin D3 analogues with a non-natural triene system by thermal sigmatropic rearrangements

1α,25-(OH)2-9α-Methylvitamin D3 (4), the first known analogue of the natural hormone 1α,25-(OH)2D 3 (3) with an alkyl substituent at C-9, and two 1α,25-(OH) 2-9-methylene-10,19-dihydrovitamin D3 analogues (7 and 8) with an unprecedented non-natural triene system were synthesized by thermal isomerization of 1α,25-(OH)2-9-methylprevitamin D3 (6). Three alternative approaches (Sonogashira, Stille, or stereoselective dehydration of a tertiary propargyl alcohol) have been successfully used to construct the dienyne precursors of previtamin 6 possessing two methyl groups capable of participating in the [1,7]-sigmatropic hydrogen shift.