1421640-71-2

Upstream product

• 1461-22-9 tributyltin chloride 
• 116506-67-3 TB 

Downstream Products

• 1421640-72-3 1α-[(tert-butyldimethylsilyl)oxy]-25-hydroxy-9-methylprevitamin D₃ tert-butyldimethylsilyl ether 
• 1421640-64-3 1α,25-dihydroxy-9-methylprevitamin D₃ 
• 1421640-63-2 1α,25-dihydroxy-9α-methylvitamin D₃ 
• 1421640-65-4 1α,25-dihydroxy-9-methylene-10(S),19-dihydrovitamin D₃ 
• 1421640-66-5 1α,25-dihydroxy-9-methylene-10(R),19-dihydrovitamin D₃ 
• 1421640-70-1 1α,3β-bis[(tert-butyldimethylsilyl)oxy]-25-hydroxy-9-methyl-9,10-secocholesta-5(10),8-dien-6-yne 

Relevant academic research and scientific papers

Synthesis of 9-alkylated calcitriol and two 1α,25-dihydroxy-9- methylene-10,19-dihydrovitamin D3 analogues with a non-natural triene system by thermal sigmatropic rearrangements

1α,25-(OH)2-9α-Methylvitamin D3 (4), the first known analogue of the natural hormone 1α,25-(OH)2D 3 (3) with an alkyl substituent at C-9, and two 1α,25-(OH) 2-9-methylene-10,19-dihydrovitamin D3 analogues (7 and 8) with an unprecedented non-natural triene system were synthesized by thermal isomerization of 1α,25-(OH)2-9-methylprevitamin D3 (6). Three alternative approaches (Sonogashira, Stille, or stereoselective dehydration of a tertiary propargyl alcohol) have been successfully used to construct the dienyne precursors of previtamin 6 possessing two methyl groups capable of participating in the [1,7]-sigmatropic hydrogen shift.