142165-64-8

Basic information

• Product Name: (S)-2-[(1-Benzyloxycarbonyl-2,3-dihydro-1H-indole-5-carbonyl)-amino]-pentanedioic acid diethyl ester
• CAS NO: 142165-64-8
• Molecular Weight: 482.533
• Mol File: 142165-64-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-2-[(1-Benzyloxycarbonyl-2,3-dihydro-1H-indole-5-carbonyl)-amino]-pentanedioic acid diethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-[(1-Benzyloxycarbonyl-2,3-dihydro-1H-indole-5-carbonyl)-amino]-pentanedioic acid diethyl ester(142165-64-8)
• EPA Substance Registry System: (S)-2-[(1-Benzyloxycarbonyl-2,3-dihydro-1H-indole-5-carbonyl)-amino]-pentanedioic acid diethyl ester(142165-64-8)

Safety Data

• Hazardous Substances Data: 142165-64-8(Hazardous Substances Data)

Upstream product

• 15861-30-0 2,3-dihydro-1H-indole-5-formic acid 
• 142165-63-7 1-carbobenzoxy-5-carboxyindoline 
• 501-53-1 benzyl chloroformate 

Relevant articles and documents

Antirheumatic agents. I. Novel methotrexate derivatives bearing an indoline moiety

Various novel methotrexate (MTX) derivatives bearing an indoline moiety were synthesized and tested for biological activities using human peripheral blood mononuclear cell (hPBMC) and human synovial cells (hSC) derived from patients with rheumatoid arthritis (RA). Compounds having potent activity in vitro were further evaluated using an adjuvant arthritis model in vivo. N- [1-(2,4-Diamino-6-pteridinylmethyl)indoline-5-carbonyl]-L-glutamic acid 2f showed more potent activities than MTX in vitro and in vivo, and N-[1-(2,4- diamino-6-pteridinylmethyl)-indoline-5-carbonyl]-L-2-aminoadipic acid 2d exhibited fairly good activities in vitro and considerable activity in vivo. Compound 2d was, as expected, not sensitive to folyl-polyglutamate synthetase (FPGS) and did not undergo polyglutamation, a process which may be responsible for a side-effect during MTX therapy.