15861-30-0

Basic information

• Product Name: 2,3-DIHYDRO-1H-INDOLE-5-CARBOXYLIC ACID
• Synonyms: 2,3-DIHYDRO-1H-INDOLE-5-CARBOXYLIC ACID;INDOLINE-5-CARBOXYLIC ACID;Indoline-5-carboxylic acid ,97%;2,3-Dihydro-1H-indole-5-carboxylic acid methyl ester;1H-Indole-5-carboxylic acid, 2,3-dihydro-;5-carboxylindoline
• CAS NO: 15861-30-0
• Molecular Formula: C₉H₉NO₂
• Molecular Weight: 163.17
• Mol File: 15861-30-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 369.037 °C at 760 mmHg
• Flash Point: 176.987 °C
• Appearance: /
• Density: 1.284 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.611
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: 2,3-DIHYDRO-1H-INDOLE-5-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-DIHYDRO-1H-INDOLE-5-CARBOXYLIC ACID(15861-30-0)
• EPA Substance Registry System: 2,3-DIHYDRO-1H-INDOLE-5-CARBOXYLIC ACID(15861-30-0)

Safety Data

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45
• Hazardous Substances Data: 15861-30-0(Hazardous Substances Data)

Usage

Chemical Properties

Light yellow solid

InChI:InChI=1/C9H9NO2/c11-9(12)7-1-2-8-6(5-7)3-4-10-8/h1-2,5,10H,3-4H2,(H,11,12)

Upstream product

• 1011-65-0 5-methoxycarbonylindole 
• 141452-01-9 2,3-dihydro-1H-indole-5-carboxylic acid methyl ester 
• 1670-81-1 1H-Indole-5-carboxylic acid 

Downstream Products

• 141452-01-9 2,3-dihydro-1H-indole-5-carboxylic acid methyl ester 
• 142165-64-8 (S)-2-[(1-Benzyloxycarbonyl-2,3-dihydro-1H-indole-5-carbonyl)-amino]-pentanedioic acid diethyl ester 
• 142165-67-1 (S)-2-[(1-Benzyloxycarbonyl-2,3-dihydro-1H-indole-5-carbonyl)-amino]-hexanedioic acid dimethyl ester 
• 156578-52-8 5-Chlorocarbonyl-2,3-dihydro-indole-1-carboxylic acid benzyl ester 
• 153247-93-9 1-acetylindoline-5-carboxylic acid 
• 142165-63-7 1-carbobenzoxy-5-carboxyindoline 
• 339007-88-4 1-(tert-butoxycarbonyl)indoline-5-carboxylic acid 

Relevant articles and documents

Cyclin-dependent kinase inhibitors and application thereof

The invention relates to compounds used as cyclin-dependent kinase inhibitors and application thereof, belonging to the field of medical chemistry. Specifically, the invention provides the compound asshown in a formula I which is described in the specification, or isomers, pharmaceutically acceptable salts, solvates, crystals or prodrugs thereof, preparation methods thereof, pharmaceutical compositions containing the compounds, and application of the compounds or the compositions to treatment of cancer, tissue hyperplasia diseases or inflammatory diseases. The compounds of the invention havegood inhibitory activity to CDK7 and are highly expected to be developed into a therapeutic agent for cancer, tissue hyperplasia diseases and inflammatory diseases.

A new photolabile linker for the photoactivation of carboxyl groups

A new photolabile linker enabling nucleophilic cleavage of a carboxyl functionality upon irradiation with UV light (>290 nm) was developed. When the photocleavage is carried out in the presence of primary or secondary amines, amides are obtained in high yields and purifies, while the intramolecular version of this reaction leads to heterocycles via a cyclorelease mechanism.