142167-65-5

Upstream product

• 141379-53-5 (3S,5S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-5-[2-((S)-4-isopropyl-2-thioxo-thiazolidin-3-yl)-2-oxo-ethyl]-pyrrolidin-2-one 
• 141355-57-9 3(S)-3-<(R)-1'-tert-butyldimethylsilyloxyethyl>-5-acetoxypyrrolidin-2-one 
• 141355-43-3 4-{(2S,4S)-4-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-5-oxo-pyrrolidin-2-yl}-3-oxo-butyric acid 4-nitro-benzyl ester 

Downstream Products

• 142167-66-6 (6S,7aS)-6-((R)-1-Hydroxy-ethyl)-2,5-dioxo-hexahydro-pyrrolizine-3-carboxylic acid 4-nitro-benzyl ester 
• 141355-50-2 (6S,7aS)-6-((R)-1-Hydroxy-ethyl)-5-oxo-2-phenylsulfanyl-5,6,7,7a-tetrahydro-1H-pyrrolizine-3-carboxylic acid 4-nitro-benzyl ester 
• 141355-45-5 (6S,7aS)-2-(Diphenoxy-phosphoryloxy)-6-((R)-1-hydroxy-ethyl)-5-oxo-5,6,7,7a-tetrahydro-1H-pyrrolizine-3-carboxylic acid 4-nitro-benzyl ester 
• 142167-67-7 (6S,7aS)-6-((R)-1-Hydroxy-ethyl)-2-[2-(4-nitro-benzyloxycarbonylamino)-ethylsulfanyl]-5-oxo-5,6,7,7a-tetrahydro-1H-pyrrolizine-3-carboxylic acid 4-nitro-benzyl ester 
• 141355-46-6 4-[(6S,7aS)-6-((R)-1-Hydroxy-ethyl)-3-(4-nitro-benzyloxycarbonyl)-5-oxo-5,6,7,7a-tetrahydro-1H-pyrrolizin-2-ylsulfanyl]-pyrazolidine-1,2-dicarboxylic acid bis-(4-nitro-benzyl) ester 
• 141355-44-4 2-Diazo-4-[(2S,4S)-4-((R)-1-hydroxy-ethyl)-5-oxo-pyrrolidin-2-yl]-3-oxo-butyric acid 4-nitro-benzyl ester 

Relevant academic research and scientific papers

The First Asymmetric Total Synthesis of Thienamycin-like γ-Lactam and its Analogue

The asymmetric total synthesis of thienamycin-like γ-lactam 1 and its analogue 2 has been accomplished by utilising highly diastereoselective alkylation of tin(II) enolate 5 on acyl imine obtained in situ from chiral 3-substituted 5-acetoxypyrrolidin-2-on